Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"sterol sponge"”.
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Membranous sterol dynamics and interactions with amphotericin B
Sterols are ubiquitous membrane-active molecules that regulate the fluidity cellular membranes. Specifically, cholesterol (Chol) plays an active role in modifying the functionality of the membrane proteins. Chol is vital for cell function, as it is essential to a myriad of biochemical and …
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A synthesis enabled understanding of Amphotericin B leading to derivatives with improved therapeutic indices
… AmB predominantly exists as an extramembranous sterol sponge that primarily kills yeast and human cells by binding and extracting sterols in a mycosamine dependent fashion. Additionally, the C2’-OH and C3’-NH3+ are critical residues on the mycosamine appendage, which are responsible for …
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Amphotericin B extracts ergosterol faster than fungi can make it
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Structural studies of membrane-associated complexes by solid-state NMR
… interactions. It is a complex mixture of lipids, sterols, and proteins, the exact composition of which directly regulates all extracellular interactions and trafficking of materials. The inherent asymmetry of the plasma membrane composition is directly involved in cell signaling processes and …