Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"steroid-resistant"”.
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Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome
… the podocytopathies, usually characterized by steroid-resistant nephrotic syndrome (SRNS). The first part of the thesis focused on IC-MPGN and C3G. We found likely pathogenic (LP) variants in complement alternative pathway genes in 18% of patients and describe, for the first time, …
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Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells
… lines of acute lymphoblastic leukaemia (ALL; steroid sensitive and steroid resistant cells), osteosarcoma, hepatoblastoma and medulloblastoma tumours. An initial assessment of whether the levels of NEIL3 expression are indicative of the response of paediatric tumours to sensitivity to DNA …
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Microbial interactions with epithelial surfaces.
… production has been shown to induce corticosteroid resistance in human T cells in vitro (corticosteroids are the most common treatment for atopic dermatitis), thus linking superantigens with more severe cases of atopic dermatitis. Past atopic dermatitis studies have focused on select …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… management of broad immunosuppression by corticosteroids has been largely unchanged in several decades. With many patients exhibiting steroid-resistant or steroid-refractory disease, newer therapies are needed. Murine modeling of cGVHD has allowed for greater understanding of disease pathogenesis …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… would enhance tumour sensitivity to steroids.In plasma cells, combination of Dasatinib and dexamethasone at clinically relevant concentrations induced apoptosis of human myeloma cell lines and exhibited synergy. Cell cycle analysis showed reduction in the proliferative compartment …
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The immunomodulatory properties of Vitamin D in vitro and in vivo
… for asthma treatment is glucocorticoids (steroids), and the majority of patients respond to steroids with an improvement in lung function (Steroid Sensitive; SS). However a proportion of asthmatics do not respond to steroids with improvement in lung function (Steroid Resistant; SR), who …
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Mutationsanalyse der Gene NPHS2 und WT1 bei Patienten mit steroidresistentem Nephrotischen Syndrom im Kindesalter
Das steroidresistente Nephrotische Syndrom ist eine heterogene Erkrankung, für die bereits einige verantwortliche Gene identifiziert werden konnten. <br>Die autosomal-rezessiv vererbte Form (srINS) ist charakterisiert durch Manifestation im frühen Kindesalter, eine rasche Progression in die TNI und …