Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"steroid receptor"”.
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Steroid receptor crosstalk in breast cancer cells.
… by estrogens and progesterone and both estrogen receptor (ER) and progesterone receptor (PR) have been shown to play prominent roles in breast cancer progression. It has also been demonstrated that co-treatment of breast cancer cells with corticosteroids and 17β-estadiol (E2) can have opposing …
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Chemical Approaches to Inhibiting the Estrogen Receptor-Steroid Receptor Coactivator Interaction
… unfortunately, only weakly bind to the estrogen receptor a.
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Design and Synthesis of Small Molecule Regulators of Steroid Receptor Action
… of coactivator binding inhibitors. The estrogen receptor contains a region in the ligand binding domain where coactivator proteins for transcription are able to dock. Using a small molecule specifically designed to bind to this region with a high affinity effectively inhibits transcription. …
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Selection and Characterization of a Steroid Receptor DNA Binding Domain-Based Repressor of Estrogen Response Element Containing Promoters
… repression of both constitutive and estrogen receptor induced transcription on a cERE containing promoter and on a natural pS2 promoter. The FdDBD5K chimera should be a useful new tool for controlling the transcription of ERE-containing promoters.
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The effect of photoperiod on central steroid receptor expression and plasma hormone concentration in the ring dove (Streptopelia Risoria)
… together with the expression of androgen receptor immunoreactivity (ARir) and progesterone receptor immunoreactivity (PR-ir) within the brain and anterior pituitary gland of both male and female ring doves. Quantitative analysis revealed that there was no significant variation (P>0.05) in …
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Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
… Second, patient treatment options are limited. Steroid resistance is the major barrier for effective treatment and this study seeks to evaluate steroid receptor expression patterns in COPD patient and control subjects to better understand mechanisms of resistance. The aim of this study is to …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
PART I: STEROID RECEPTOR CO-ACTIVATOR 3 (SRC-3) EXPRESSION IN LUNG CANCER AND ITS ROLE IN REGULATING CANCER CELL SURVIVAL AND PROLIFERATION Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in …
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
… function genes relevant to HIV acquisition, on steroid receptor activity, and on HIV replication. Analysis of expression of select pro- and anti- inflammatory genes revealed that, DPV exerts gene-specific pro-inflammatory and cytotoxic effects on cervical cells and tissue. Co-stimulation with …
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Small Angle X-ray Scattering study of conformational changes in steroid responsive activator (SRA) RNA upon binding with suppressor protein SHARP
… and proliferation are known to be influenced by steroid stimulation. The steroid receptor activator (SRA) RNA is a large RNA transcript indicated to be an epigenetic regulatory component in the steroid receptor coactivator-1 (SRC-1) acetyltransferase complex. It is<strong> </strong>needed for a …
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Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens
… effects, molecular mechanisms of action and steroid receptor involvement in gene expression by MPA as compared to NET and progesterone (P4) in the End1/E6E7 and HeLa cell line models for the endocervical epithelium, a key point of entry for pathogens in the lower female genital tract (FGT). …
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Rhenium and technetium-labeled progestins, the development of receptor-directed agents for diagnostic imaging or therapy
… of developing diagnostic imaging agents for steroid receptor-positive tumors that are labeled with the readily available radionuclide technetium-99m, three conjugate systems have been prepared in which a progestin is linked to a metal chelate system. These are bis-amino bis-thiol (BAT or …
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Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants
… differential selectivity to towards different steroid receptors, in particular the glucocorticoid receptor (GR). In order to investigate this hypothesis, the regulation of selected genes was investigated in cervical tissue explants from premenopausal, HIV-1negative, and contraception negative …
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A Novel Phytoestrogen that Acts as an Agonist for Human Estrogen Receptors.
Estrogen is the natural agonist of the estrogen receptor (ER). However, certain plant-derived compounds or phytoestrogens have been identified that mimic estrogens and act as agonists and/or antagonists of ERs, depending on subtype and target tissue. Understanding how phytoestrogens interact with …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
In Breast Cancer(BCa), steroid receptors play a key role in the progression of the majority tumours. Oestrogen Receptor-α (ERα), for example,drives the growth of approximately 70% of tumours and is therefore a useful therapeutic target for this disease.Interestingly, the Androgen Receptor (AR) is …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… machinery (1). Hormone-activated nuclear receptors (NRs) are well characterized transcriptional factors (2) that bind to the promoters of their target genes and recruit primary and secondary coactivator proteins which possess many enzymatic activities required for gene expression (1,3,4). …
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Dietary Soy Protein Isoflavonoid Effects on the Reproductive Tract of the Nonhuman Primate and Neoplastic Human Prostate Gland
… hormone concentrations, prostate tissue sex steroid receptor expression levels, androgen and estrogen receptor polymorphisms, and diet have all been proposed to explain these discrepancies in prostate cancer incidence in men living in Western countries when compared to men living in Asia. …
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Estrogen Receptors and Estrogen-Regulated Genes in the Male Reproductive Tract
Estrogen receptor-alpha (ERalpha) is essential for male fertility. The bisexual role and importance of estrogen in reproduction was established by the previous studies. However, there is considerable variation, both within and between species, in reports of nuclear steroid receptor localizations in …
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Detailed Analysis of Transcriptional Regulation by Activation Functions-1 and -2 of the Human Estrogen Receptor
The human estrogen receptor (ER), is a 66 kilodalton, ligand-inducible transcription factor that regulates the transcription of estrogen-responsive genes. Like other steroid hormone receptors, the ER is a modular protein that can be divided into separable domains with specific functions, such as …
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Development and Application of a Fluorescence Anisotropy Microplate Assay for Analyzing the Interaction of Steroid Hormone Receptors With DNA and Coactivators
A key event in estrogen receptor (ER)-mediated transcription is the binding of the ER to its DNA recognition sequence, the estrogen response element (ERE). To analyze this interaction, we used ultra low-volume microplates to develop the simple and rapid fluorescence anisotropy microplate assay …
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