Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"steroid hormone receptor"”.
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Binding sites in the nuclear envelope for cytoplasmic glucocorticoid receptor complex
… cytoplasmic triamcinolone acetonide-receptor complex has been purified 3 000 fold from rat liver cytosol. The isolated complex sedimented as a single radioactive peak on a 5 - 20% sucrose gradient. Nuclear envelopes isolated from purified rat liver nuclei were found to contain binding …
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Genetic Analysis Of Rhoa Signaling During Epithelial Morphogenesis In Drosophila
… The candidate gene Eip78C encodes a nuclear steroid hormone receptor previously identified as having an important role in metamorphosis.
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Comparative analyses of aryl hydrocarbon receptor structure and function in marine mammals
… in laboratory animals. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, mediating the expression of a suite of genes in response to exposure to DLC and structurally related chemicals. Species-specific differences in AHR structure can affect an organism’s …
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Interactions of Steroid Hormone Receptors With Coactivators and DNA
II Steroid hormone receptors (HR) activate gene transcription through binding to ligands, locating specific hormone response elements (HREs) on DNA, recruiting coactivators and then chromatin remodeling complexes and ultimately the basal transcription machinery. In vivo data suggests that the …
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Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression and Hormone Regulation in Human Placental JEG-3 Cells
… mechanisms of the tissue-specific expression and steroid hormone regulation of the hGnRH gene in the human placenta. The results showed that all of the previously identified four elements are required for the full activity of the hGnRH upstream promoter in JEG-3 cells, while the element 4 (FP4, …
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Temporal and spatial controls of cell fate specification in the cerebellum
… encoding Fgf8 and a dominant-negative FGF receptor. This FGF-dependent domain of Atoh1 is regulated independently from the specification of rhombic lip derivatives, suggesting a novel role for both Atoh1 and FGF signalling in rhombomere1. Analysis of triple knockout FGF receptor mutants and …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… Although TNBC lacks estrogen and progesterone receptors, 15-40% of TNBC patients express the glucocorticoid receptor (GR). Women with TNBC that express high levels of GR have poor outcomes. We hypothesize that GR is a key mediator of advanced cancer phenotypes in TNBC. Altered signaling …
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Zur Funktion der Kinase Dyrk1A im Gehirn der adulten Maus
… a GTPase of the Septin family, and Arip4, a steroid hormone receptor cofactor with ATP-dependent chromatin-remodelling activity. These interactions were confirmed in mammalian cells by coimmunoprecipitation. By in situ-hybridisation, the coexpression of Dyrk1A with the genes of both …
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Molecular mechanisms regulating implantation
… stroma. These stages are tightly regulated by steroid hormones Estrogen (E) and Progesterone (P). Genomic profiling in mice has uncovered novel steroid regulated genes in the uterine luminal epithelium and also in the stroma which regulate implantation. Recent evidence also points to the fact …
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Studien zur Expression von Klasse-1-Histon-Deacetylasen im humanen Endometrium sowie in Endometrium- und Mamma-Karzinomen
… expression is restrained. HDACs are involved in steroid-hormone dependent gene expression and into carcinogenesis. HDAC-inhibitors induce differentiation of endometrial and malignantly transformed cells. They inhibit proliferation and induce apoptosis in tumor cells. Thus HDACs are therapeutic …
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Dietary Soy Protein Isoflavonoid Effects on the Reproductive Tract of the Nonhuman Primate and Neoplastic Human Prostate Gland
… screening, body mass index, serum and tissue hormone concentrations, prostate tissue sex steroid receptor expression levels, androgen and estrogen receptor polymorphisms, and diet have all been proposed to explain these discrepancies in prostate cancer incidence in men living in Western …
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The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
The molecular actions initiated by the steroid hormone estrogen elicit a multitude of biological effects in physiological and pathophysiological processes. Estrogen acts via its cognate steroid hormone receptor, estrogen receptor alpha (ERalpha) or beta (ERalpha, to fulfill these biological …
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Zur Funktion von Leupaxin beim Karzinom der Prostata
… Leupaxin die transkriptionelle Aktivität dieser Steroidhormonrezeptoren erhöhen. Funktionelle Analysen mittels der RNA-Interferenz-Technologie ergaben weiterhin, dass androgen-abhängige LNCaP-Zellen mit reduzierter Leupaxin-Expression ihre Morphologie verändern, sich ablösen und apoptisch werden. …