Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"stereotactic radiosurgery"”.
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A Complete Dosimetric Model of the Gamma Knife Perfexion Using Penelope Monte Carlo Codes
… diameter at the focus. Planning for Gamma Knife stereotactic radiosurgery (GK SRS) is performed using images from computed tomography (CT) and/or magnetic resonance (MR) imaging, as well as manual skull measurements. The manufacturer's software used to plan the delivery of these treatments uses a …
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HIGH FIELD MAGNETIC RESONANCE IMAGING-BASED GEL DOSIMETRY FOR SMALL RADIATION FIELDS
… such as intensity modulated radiotherapy, and stereotactic radiosurgery, as well as for cellular and preclinical radiobiology studies (very small fields, <1 mm diameter). Radiation dose characteristics for these small fields are difficult to determine in multiple dimensions because of steep …
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
… to alternative targeted treatments such as stereotactic radiosurgery or the vascular endothelial growth factor inhibitor bevacizumab. The main objective of this thesis was to investigate targeting of the receptor tyrosine kinase MERTK as a potential pharmacological intervention in …
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Development of a Comprehensive Linac-based Quality Assurance Program for a Retrofitted Micro-MLC SRS System
In Stereotactic Radiosurgery, one of the most import factors that must be measured is the accuracy of the localization system, whether it be lasers or camera system; and the coincidence of the localized isocenter to the radiation isocenter. According to TG-142 the minimum deviation between the …
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Characterization of Oslds For Use In Small Field Photon Beam Dosimetry
… Center (RPC) mailable remote audit tool used for stereotactic radiosurgery (SRS) single beam dosimetry. A prototype phantom was designed and built housing nanoDot (Landauer Inc., Glenwood, IL) Al<sub>2</sub>O<sub>3</sub>:C optically stimulated luminescence dosimeters (OSLDs) whose visible active …
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Radiotherapy for head and neck paragangliomas: A 10 year retrospective review 2005-2014 at Groote Schuur Hospital and UCT Private academic hospital
… decades there has been increasing evidence that radiosurgery and radiotherapy management of skull-base paragangliomas is as effective as microsurgical resection and carries less morbidity. This 10 year retrospective review of 24 patients in a single institution, treated over 10 years assesses …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… is limited to surgical lesion eradication or stereotactic radiosurgery. CCM affects up to 0.5% of the human population and can occur either in a sporadic or familial form. Loss-of-function mutations in any of three genes CCM1, CCM2 and CCM3 have been associated to familial CCM. Postnatal …
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End-to-end testing of the Leksell Gamma Knife Icon system
The Leksell Gamma Knife Icon is a stereotactic radiosurgery system that is used to non-invasively treat brain lesions. It incorporates 192 fixed cobalt-60 sources, which ensures the highest degree of accuracy during treatment due to the minimization of potential error from stationary sources. The …
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Commissioning of Micro-Cube Thermoluminescent Dosimeters For Small Field Dosimetry Quality Assurance In Radiotherapy
… and accuracy of TLD micro-cubes for use in stereotactic radiosurgery (SRS) remote auditing quality assurance (QA) for treatment centers participating in clinical trials. This study tested the hypothesis that TLD micro-cubes could be commissioned to evaluate small field dosimetry, and provide …
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Clinical symptoms and volumetric radiological responses of acoustic neuroma patients, treated with hypo-fractionated image guided radiotherapy (IGRT) at Groote Schuur hospital between 2013 and 2016
Background: Stereotactic radiosurgery (SRS) is the gold standard for treatment of small and medium sized tumours, although fractionated regimens are well described. Access is limited in resource-constrained settings. There are no South African data describing outcomes of AN patients treated with …
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Advancing Radiotherapy Treatment Through Artificial Intelligence-Driven Approaches
… three parts: (1) Streamlining and standardizing Stereotactic Radiosurgery (SRS) workflow with AI. In this part, an AI-driven auto-segmentation and labeling platform was firstly developed for SRS patients with multiple brain metastases (mBMs). This platform can automatically segment out mBMs and …
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An optical computed tomography scanner for three dimensional gel dosimetry of radiotherapy dose distributions
… to clinical appeal. A specific application of stereotactic radiosurgery was targeted, where small dose distributions are delivered with high spatial accuracy to cranial tumours. Improvements in the practicality and efficiency of optical CT scanning were initially sought by elimination of the …