Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"stereospecificity"”.
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Structure and stereospecificity of metal complexes / by Trevor William Hambley
Typescript (photocopy)
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Stereochemistry, isotope effects, and inhibition of terpene biosynthesis: I. Stereospecificity and mechanism of monoterpene cyclases. II. Inhibition by heteroatom analogs of carbocation intermediates
Stereospecificity and mechanism of monoterpene cyclases have been investigated by use of deuterium and tritium labeled substrates. The stereochemistry of the terminating deprotonation in limonene biosynthesis was elucidated by radiochemical degradation of ($\sp3$H) carvoximes. Limonene cyclases …
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Development and Optimization of an Assay of Scp-2/Thiolase Activity in Rat Liver, and a Study of the Substrate Stereospecificity of Permfe-2
… activites as well. An investigation of the stereospecificity of another peroxisomal enzyme from rat liver, perMFE-2, is also described. The conclusions from this study indicate that perMFE-2 harbors both the hydratase and dehydrogenase activities responsible for normal production of …
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Investigations in Enzyme Stereospecificity: I. The Stereochemistry of Cis-Double Bond Formation in Dolichol and Natural Rubber Biosynthesis. II. The Stereochemistry of Carbon-Sulfur 4ond Reduction by Methyl Coenzyme Reductase
Dolichol, a poly-cis polyprenol, is biosynthesized from isopentenyl pyrophosphate, IPP, and farnesyl pyrophosphate, FPP, as a branch from the pathway to squalene and cholesterol. Natural rubber, also a poly-cis polyprenol, is biosynthesized from Hevea latex in the same manner. The stereochemical …
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Studies on the mechanism of action of propionyl-CoA carboxylase
… propionylâ CoA in the absence of ATP. Absolute stereospecificity was observed with regard to which a-hydrogen is replaced during the addition.
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Triplex Diels-Alder reactions of beta-methylstyrenes. Density functional investigation of pion-pion interactions
… is found to occur with a high degree of syn stereospecificity.
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Mechanisms of Flavin-Dependent Monooxygenases Involved in Natural Product Chemistry
… biological sources and low yields that can lack stereospecificity from synthetic sources. It is paramount to solve these issues and to develop novel natural products to combat the growing antimicrobial resistance crisis, which was responsible for ~5 million deaths in 2019 alone. One approach is …
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Synthesis, structure and chirality of some neutral cobalt (III) complexes
… circular dichroism spectra in every case. No stereospecificity was observed in these systems or for the complexes bis(2 , 4-pentanedionato)aminoacidato- cobalt(III) where the amino acid is sarcosine, S-proline and S-serine. A convenient, high yield synthesis of tris(2 …
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Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols
… contiguous stereocenters. Catalyst control and stereospecificity were simultaneously leveraged to attain exceptional control of the product stereochemistry. Beyond the utility of this protocol, the strategy demonstrated here should inspire the development of methods providing complete sets of …
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An investigation into fungal metabolism of halogenated and related steroids
… as arising because of the lack of regio- and stereospecificity of the hydroxylase enzyme(s) involved.
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Asymmetric reduction using enzymes and Chiral chemical reagents
… The reaction was quantitative and complete stereospecificity was demonstrated using chiral naphthyl isocyanates and HPLC. (6R)- 5,10-Methenyltetrahydrofolate was isolated in 28% yield and hydrolysed to give (6S)-5-formyltetrahydrofolate. The necessary enzymeswere immobilised for recovery and …
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New Methods for Palladium-catalyzed Decarboxylative Benzylation, Arylation and Dearomatization Reactions
… with acetylides proceeded with high stereospecificity to provide enantioenriched 1,1-diarylethynyl methanes, and we are unaware of any other method for the direct synthesis of such motifs. However, racemization was observed in the decarboxylative coupling of enantioenriched benzylic …
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The Modified Stereospecific Stille Reaction: Palladium-Catalyzed Cross-Coupling Reactions Involving Secondary and Tertiary Alkyl Carbastannatranes
… scope of reactants, and even proceed with high stereospecificity. The development of a general system that enables a broad scope of reactants to be employed in reactions with high sterespecificity would be transformative in the field of organic synthesis and drug development. Herein, in the …
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Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
… (CLAPs), which can be used to study AChE stereospecificity.</P>
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Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
… (CLAPs), which can be used to study AChE stereospecificity.</P>
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Synthesis and pharmacological evaluation of conformationally constrained models of hydrocortisone
… receptors exhibit a relatively high degree of stereospecificity, a property shared by enzymes. c. Most receptor-like substances which have been isolated have been found to be proteolipid complexes, some of which may include phospholipids and prostaglandins if they are membrane-bound.</p><p>Its …
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Radical based molecular design of discrete and stereoregulated oligomers via photomediated RAFT single unit monomer insertion (photo-RAFT SUMI)
… monomers has spontaneously resulted in a trans- stereospecificity within the 5-member ring during each step of insertion. This exciting finding has ultimately led to the final success of controlling both monomer sequence and stereochemistry by Photo-RAFT SUMI with further improvements. A library …
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