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Showing 1 to 4 of 4 for “"stereochemically defined"”.
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The Synthesis and Photophysical Properties of New Polymetallic Complexes Designed for Use in Photoinitiated Electron Collection
The goal of this research was to develop stereochemically defined multimetallic systems for use as light absorbers and electron donor / light absorber dyads in photoinitiated electron transfer and electron collection. The basis for the stereochemical control was provided by the symmetric bridging …
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Palladium (II) / sulfoxide - promoted strategies for efficient and selective allylic C-H oxidations
… (avg. 92% ee). Additionally, we observed stereochemically-defined substitution on the isochroman to be well-tolerated, with asymmetric catalysis affording either enhanced diastereoselectivity or a modest turnover. Mechanistic insights indicated that functionalization of the …
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Towards the automation of small molecule synthesis: The development of an impact-prioritized list couplings and blocks for building block assembly of most linear natural products
General synthetic methods that broadly enable the preparation of functionally important organic small molecules can be exceptionally impactful. Identification of such methods has traditionally been done on an ad hoc basis and largely driven by the goal of enabling a customized approach to each …
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Design and synthesis of novel non peptidomimtic beta-secretase inhibitors in the treatment of Alzheimer's disease
… δ-aminocyclohexane carboxylic acid motif with stereochemically defined substitution to incorporating such a constrained core in potential BACE1 inhibitors. This fragment, endowed with reduced peptidic character, is not known in the context of peptidomimetic design. In particular, we envisioned …