Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"stent thrombosis"”.
-
Eine Stentimplantation außerhalb der FDA-Indikationen für DES ist unabhängig von der Wahl des Stenttyps mit einer erhöhten Stentthromboserate verbunden
For decades, implantation of stents in coronary lesions after baloon dilatation has been the gold standard therapy in stenotic coronary artery disease. With the use of bare-metal stents, the cardiologist often saw an instent restenosis, which led to the invention of drug-eluting-stents. …
-
Untersuchung von Krankenhauskomplikationen nach elektiver perkutaner transluminaler Koronarangioplastie bei kombinierter Vorbehandlung mit Ticlopidin und Azetylsalizylsäure
… with an increased use of coronary artery stenting in percutaneous transluminal coronary angioplasty (PTCA) was examined. Study endpoints were procedural success, the rate of PTCA-induced complications (necessity of reintervention, myocardial infarction, death, ischemic and hemorrhagic …
-
Clinical outcome and Predictive factors of Coronary aneurysm after Percutaneous Coronary Intervention
… the adjacent reference vessel) at the site of stent implantation are rare and the reported incidence varies from 0.3% to 6%(Aoki et al., 2008). A new term, peri-stent contrast staining (PSS) was defined as contrast staining outside the stent contour extending to ≥20% of the stent diameter which …
-
Computational model of local intravascular drug delivery
Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical to examine factors that alter local biologic outcome. The central hypothesis of …
-
Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
Coronary stents have changed the way in which coronary artery diseases are managed. Although bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has …
-
Novel strategies for optimising drug release from medicinal implants
In-stent restenosis (ISR) is a significant limitation of percutaneous coronary revascularisation procedures, occurring in around 30% of patients. Implantation of the sent produces an intense inflammatory response. This leads to high levels of smooth muscle cell (SMC) proliferation and migration, …
-
Improving outcomes in patients with coronary heart disease using national registers and platelet function testing
… a clinically applicable cut-off value to predict stent thrombosis or new onset MI in patients with dual anti-platelet therapy. Using platelet function testing, a loading dose of either prasugrel or ticagrelor on top of a previous loading dose of clopidogrel, did not cause a pharmacodynamic …
-
Clinical, Invasive and Non-Invasive Factors Affecting Outcomes in Patients with Acute Coronary Syndromes
… costs, selective criteria for drug-eluting stents (DES), which reduce restenosis, were developed in 2003 at Liverpool Hospital, Sydney, Australia. Clinical outcomes were examined in 2075 patients undergoing PCI (29% ≥1 DES and 71% bare metal stent [BMS]); there were no differences …
-
Impact of Transradial Approach in Patients with High Risk Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention and Abciximab on In-Hospital Clinical Outcomes and Bleeding Complications
… infarction, repeat revascularization and stent thrombosis. The secondary endpoint was major bleeding and any bleeding events of bleeding including access site hematoma, intracranial hemorrhage and other bleeding complications. RESULTS: After propensity score matching, there were no …
-
Surface modification of traditional and bioresorbable metallic implant materials for improved biocompatibility
… local tissue effects in the long-term. Permanent stenting can lead to late-stent thrombosis and in-stent restenosis. Metallic pins and screws for fracture fixation can corrode and fail, cause loss of bone mass, and contribute to inflammation and pain at the implant site, requiring reintervention. …
-
Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
-
Production and characterisation of bioresorbable polymers and polymer-glass composites for application in cardiac stents
Bioresorbable polymeric cardiac stents are a promising technology for treating cardiovascular diseases, but current poly-L-lactide (PLLA) stents have been limited by poor mechanical properties and slow degradation. Materials with increased strength and stiffness are needed, to reduce the required …