Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"stem progenitor cells"”.
-
Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem …
-
Microrna Regulation of Prostate Cancer Stem/Progenitor Cells and Prostate Cancer Development
<p>Most human tumors contain a population of cells with stem cell properties, called cancer stem cells (CSCs), which are believed to be responsible for tumor establishment, metastasis, and resistance to clinical therapy. It’s crucial to understand the regulatory mechanisms unique to CSCs, so that …
-
Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
… dental pulp, vascular tissue and bone. Various stem/progenitor cell populations are present in tissues adjacent to an articular cartilage defect including subsets of cells that have the ability to differentiate into cartilage-like tissue. Furthermore, several factors have been elucidated that …
-
FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis
… tutkimusartikkelista “FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis” toimii syventävien opintojen kypsyysnäytteenä. Tutkimusartikkeli on lähetetty vertaisarvioon Journal of Dental Research -lehteen. Leukanivel on yksi kehon käytetyimmistä nivelistä. …
-
Human Salivary Gland Stem/Progenitor Cells for Tissue Engineering, SARS-CoV-2 Susceptibility, and Neurointegration
… use these minor-gland derived salivary gland stem progenitor cells (hS/PCs) along with those isolated from major glands to understand salivary gland susceptibility to SARS-CoV-2, while also contributing data on mechanisms that might explain the ability of coronaviruses to infect salivary …
-
Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
… subtypes. Previous studies suggested a neural stem/progenitor cell (NSC) origin for gliomas, however strict exprimental evidence was still lacking. To examine the role of NSCs in glioma, we developed an NSC-specific tamoxifen-inducible nestin-cre driver mouse. When crossed to the NF/p53/Pten …
-
Neural Crest Contributions to Dental Pulp Stem/Progenitor Cells and Craniofacial Structures: Alveolar Processes, Tongue and Temporomandibular Joint
… dental development. Populations of multipotent stem cells have been identified in various dental tissues including dental pulp. Hence, identification of multipotent cells of neural crest lineage within dental pulp and delineation of neural crest contributions to various craniofacial tissues may …
-
Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone marrow (BM) and peripheral blood (PB). To …
-
Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… a population of resident (endogenous) cardiac stem cells (eCSCs). They express the stem cell factor receptor c-kit, are distributed throughout the myocardium, are clonogenic, self-renewing and multi-potent, in that they differentiate into the 3 main cardiac lineages; cardiomyocytes, smooth …
-
Isolation, characterization, and functional assessment of novel smooth muscle like stem progenitors
Vascular smooth muscle cells (VSMC) are one of the key players in the pathogenesis of cardiovascular diseases. The origin of neointimal VSMC has thus become a prime focus of research. VSMC originate from multiple progenitors cell types. In embryo the well-defined sources of VSMC include; neural …
-
Role of Sonic Hedgehog in Development of the Central Nervous System
… patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor cells. However, it has not been elucidated how Shh induces neural …
-
Identify and characterise stem cell population of the human endometrium
… of the embryo. Underpinning this cycle must be a stem cell population. The aim of this project was to characterise this stem cell population in situ in post-menopausal endometrium. To this end, Scanning electron microscopy, image analysis and biospectroscopy techniques, Fourier transform Infrared …
-
Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… Umbilical cord blood (UCB)-derived hematopoietic stem/progenitor cells (HSPC) isolated by high aldehyde dehydrogenase activity (ALDHhi) reduce hyperglycemia after transplantation into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the …
-
Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but retained the hypersensitivity seen in the intact mice. Mesenchymal stem/progenitor cells (osteoprogenitors) …
-
Cellular principles of Xenopus appendage regeneration
… that we termed Regeneration-Organising- Cells (ROCs). Upon tail amputation, ROCs are relocated from the body to the amputation plane only in regeneration-competent tadpoles. ROCs secrete multiple growth factors for the underlying stem/progenitor cell types to proliferate and grow a new …
-
Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… the molecular markers of renal stem/progenitor cells localized in the different niches of ten human preterm kidneys with gestational age ranging from 11 up to 25 weeks. Our data evidence the existence of multiple stem/progenitor pools in different zones of the human developing …
-
Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… of ovarian surface epithelium, granulosa cells, and theca cells. While the sources of ovarian surface epithelium and granulosa cells are known, the embryonic origin(s) of theca stem/progenitor cells have not been definitively identified. Here I show that theca cells derive from two …
-
Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… is the process through which male germ cells give rise to spermatozoa. Spermatogenesis is initiated from spermatogonial stem cells (SSCs) which self-renew or differentiate to give rise to differentiated progenies of germ cells. Hence understanding of SSC biology is essential to …
-
The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… focal point of my doctoral research, Sox2, is a stem cell gene that has been extensively studied for its function in stem cell maintenance and proliferation, cellular reprogramming, neurogenesis, and tumorigenesis. Sox2 is expressed and maintained in stem cells of different tissues, including the …
-
Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… gland and prostate cancer (PCa) epithelial cells, respectively. These two matrix proteins maintain key roles in the induction of migratory signaling events through their respective signaling complexes. In the first study, using combined biochemical and unbiased computational approaches, we …
Page 1 of 3