Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"stem cell niche"”.
-
Refining Our Understanding of the Hematopoietic Stem Cell Niche
… goal of studying blood-forming hematopoietic stem cells (HSCs) is to understand the mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat hematopoietic illnesses. …
-
Soluble factors and remodeling in a synthetic stem cell niche
Hematopoietic stem cells produce the body’s entire complement of blood and immune cells, in a process known as hematopoiesis. Producing half a trillion cells daily, this rare population (<0.01% of human bone marrow) possess the ability to produce multiple cell lines (differentiation) and stem cell …
-
Analysis of drug resistance and the role of the stem cell niche in leukaemia
… and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug response/resistance all require investigation. Using microenvironment-mimicking conditioned media (CM), dexamethasone (a synthetic glucocorticoid) and etoposide …
-
Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
Specialized microenvironments called niches keep stem cells in an undifferentiated and self-renewing state by producing a variety of factors. The size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis. I use the Drosophila female germline as an excellent model …
-
THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs …
-
Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
… Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including <em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em>, and <em>PMS2. </em>These genes play a critical role in repairing errors that occur in base pairing by stabilizing …
-
Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
… evidence indicates that overnutrition increases ‘stemness’: the ability of intestinal stem cells to self-renew or differentiate. The mechanistic target of rapamycin (mTOR) pathway, a central metabolic regulator, is elevated in CRC and modulates stem cell response to nutrients. Therefore, …
-
CONTROL OF CELL DIVISION AND DIFFERENTIATION IN THE ARABIDOPSIS ROOT - STUDIES ON THE AUXIN RESISTAN 3 (AXR3) GENE
Tight and balanced control of cell division and cell differentiation is crucial for plant development. In Arabidopsis, auxin signaling mediated by its repressors AUX/IAA proteins, plays a key role in mediating root development and growth. However, it is still not well understood how AUX/IAA …
-
Apical Testis Structure and the Effects of Cadmium Treatment on Spermatogenesis in Drosophila
… as a model for studying molecular, genetic and cellular aspects of human disease and physiology. Our lab has used <em>D. melanogaster</em> and related species to study the structure of the testis stem cell niche, as well as other aspects of spermatogenesis. We previously revealed a novel stem …
-
The Role of Hyaluronan in the Ocular Surface
Purpose: The extracellular matrix (ECM) has a vital role in all tissues of the body, including maintaining ocular surface homeostasis. Hyaluronan (HA) is found in the extracellular matrices of the corneal limbus and meibomian gland (MG). This dissertation evaluated the role of hyaluronan in ocular …
-
Confocal Characterization of the Apical Testes and Ultrastructural Analysis of the Seminal Visicles of Drosophila pseudoobscura
… termed "the hub" responsible for maintaining the cells associated with the stem cell niche, using antibodies raised against the hub proteins in D. melanogaster. The hub proteins probed were fasciclin III, DE-cadherin and armadillo. Fasciclin III is a glycoprotein that is associated with adhering …
-
Merlin Mediated Regulation of Hair Follicle Morphogenesis
… through a complex and delicate balance of cell death, cell proliferation and cell differentiation. Critical for regeneration and maintenance of the skin are epidermal stem cells. Within the epidermis two distinct stem cell compartments exist, the bulge and interfollicular/basal stem cell …
-
Engineering Matrix Properties for Stem Cell Culture and Gene Delivery
… tissues and frequently combines therapeutic cells, biomaterial scaffolds, and therapeutic molecules in efforts to do so. One of the primary considerations in such therapies is to orchestrate the interactions between these components to regulate the desired cellular responses. This thesis …
-
The Mechanism of the Gastric Epithelial Stem Cell Response to Metaplastic Injury
… is known about the identity of the epithelial stem cell of the gastric corpus, either during normal turnover or in response to injury. Our lab has shown that injection of the selective estrogen receptor modulator tamoxifen leads to near complete atrophy of parietal cells by 3 days and induces …
-
Molecular and physiological characterisation of selected DOF transcription factors in the model plant Arabidopsis thaliana
… in the root tip, a region that comprises the stem cell niche and cells for the perception of environmental stimuli. DOF1.2, DOF3.1 and DOF3.5 are previously uncharacterized members of the Arabidopsis DOF-family, while DOF5.2 has been shown to be involved in the phototrophic flowering response. …
-
Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
Human embryonic stem cells (hESCs) are remarkable for their ability to self-renew indefinitely and differentiate into any cell type in the human body. The differentiation of hESCs is regulated by intrinsic and extrinsic signals in the stem cell niche. Heparan sulfate proteoglycans (HSPGs) are found …
-
Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
… therapy and the diversity of cancer. In cancer, cell-to-cell interactions between tumor cells and their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported …
-
MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
Stem cells undergo self-renewal, maintaining themselves in an undifferentiated state while generating differentiated cells that are required for the tissue homeostasis or repair. One intriguing feature of stem cells is their maintenance in their respective hypoxic niche. Survival in this low-oxygen …
Page 1 of 3