Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"stem cell genes"”.
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Characterization of Genes Specifically Expressed in Embryonic and Cancer Stem Cells
ES cells are derived from the ICM of blastocyst and have ability of self-renewal, unlimited proliferation and pluripotency that differentiate into cells of all three germ layers. The stem cell genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc (c-Myc) act alone and interact with …
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Transcriptional Elongation is Important for Neural Crest Development
Neural crest cells are a multipotent cell population, which migrate from the dorsal neural tube in early vertebrate development throughout the embryo to form a variety of cell types including pigment cells, craniofacial cartilage and sensory neurons [1, 2]. Here I show that the small molecule …
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Expression Analysis and Stem Cell Engineering
… to develop tools to advance Investigations of stem cells in tissue engineering therapeutics for neurodegenerative disease and spinal cord injury. Two tools to characterize cell fate and a tool to separate a subset of neural cells were developed and evaluated. In the first study, a digital PCR …
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Stem cell differentiation study: Statistical analysis and application to microarray data
… and data mining procedures for modeling stem cell genes during the differentiation process, (2) To present biological interpretations of "sternness" genes based on time-course expression patterns and genetic networks. Stem cells have been of much interest over the past few years. Up to …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… a treatment strategy to target the cancer stem-like (CSC) population to block metastasis. Cyclooxygenase-2 (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… a treatment strategy to target the cancer stem-like (CSC) population to block metastasis. Cyclooxygenase-2 (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… that in two of the four groups the expression of stem cell gene Olfactomedin 4 was absent from the crypt though other functional genes were found to still be expressed there. Chapter 3 characterized intestinal gene expression following a single challenge of Eimeria acervulina in broiler chickens. …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia …
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… distinct subtypes each with its own unique pathogenesis, clinical behavior, and response to therapy. Chromosomal aberrations are a hallmark of ALL but alone fail to induce leukemia. Pediatric ALLs can be divided into several categories based on the expression of several genetically conserved …
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Liver fluke development: a target for parasite control?
… have identified a population of proliferative cells within Fasciola hepatica (Fasciola proliferative cellsFPCs) that resemble neoblast-stem cells, both morphologically and behaviourally. These cells are the only proliferating cells in Fasciola hepatica and can be localised using thymidine …