Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"stem cell dynamics"”.
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
… renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation of these dynamics through oncogenic mutation can predispose the epithelium to neoplastic transformation. …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
Neural stem/progenitor cells (NSPCs) play a crucial part in the evolutionary development of the human neocortex. During early postnatal development, NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… of cancer-related mortality worldwide, yet the cellular dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, …
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Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
I investigated stem cell dynamics in normal human colon by detecting somatic variants affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral clonal marks to a large cohort of patients to interpret age-related trends in clone frequencies has established the baseline stem …
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The role of CD133 in mouse incisor tooth epithelium
… isolate and characterise many different stem cell types across a wide variety of tissues. Nonetheless, to date not much has been elucidated about its function in these cells. The continuously growing mouse incisor contains a large population of epithelial stem cells that drive the …
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Investigating how Notch, and JAK/STAT Signaling Synergistically Regulate Intestinal Stem Cell Homeostasis Using Engineered Optogenetic Alleles
Stem cells are a class of undifferentiated cells that have the unique ability to give rise to a variety of specialized cell types during tissue development and growth. These cells communicate amongst one another by sending and receiving signals from multiple pathways that regulate cell fate …
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The role of space in homeostasis and preneoplasia in stratified squamous epithelia
… subject of study in biological research is the dynamics of stem cells in squamous epithelia. Given that most common human cancers develop from epithelia, understanding the rules of cell fate decision in these systems is key to explaining not only healthy tissue growth and maintenance but also …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
Majority of adult mammalian neural stem cells are quiescent, remaining in an actively maintained state of cell cycle arrest. Quiescent and actively proliferating neural stem cells can be distinguished by their transcriptional state, however, the understanding of how these gene signatures are …
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Cellular Ensembles in Alveolar Homeostasis and Repair
… damages. In adult mammalian lungs, epithelial cells are generally quiescent but can respond rapidly to repair damaged tissues. Evidence from experimental injury models in rodents and human clinical samples has led to the identification of these regenerative cells, as well as pathological …
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Notch activation and clone fate in intestinal homeostasis and inflammation
… Notch signals are important for determining cell fate between the absorptive and secretory lineage and regulating the proliferation of intestinal stem cells (ISCs). As a result, Notch is also an important pathway during disease such as inflammation and previous literature has reported …