Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"stem cell development"”.
-
Role of epigenetics in hematopoietic stem cell development
… such as molecules which stimulate hematopoietic stem cell (HSC) formation without the need for a donor. Therefore, a study was initiated to use human-induced pluripotent stem cell (hiPSC) technology to make a patient-derived, personalized HSC. Epigenetic regulators are divided into readers, …
-
Engineering hydrogel environments to direct cell fate
… in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can …
-
Towards hES cell-based therapy of Epidermolysis Bullosa
… approaches to generating keratinocytes (the main cell of the outer skin layer, epidermis) from pluripotent stem cells (human embryonic stem cells, hESCs). Undifferentiated hESCs were exposed to a complex microenvironment in organotypic cultures (to mimic conditions for epidermal stem cell …
-
Cell culture platforms with cell-cell adhesive ligands for biomedical applications
Cell behavior is regulated by a number of different mechanical and chemical cues within the extracellular microenvironment, including the surrounding matrix and neighboring cells. Although biomaterials have been engineered to present several adhesion molecules that mimic cell-extracellular matrix …
-
Intercellular Feedback in Hematopoiesis
Despite the importance of inter-cellular (between cell) communication networks in regulating homeostasis in multicellular organisms, very little is known about their topology, dynamics, or functional significance. Inter-cellular communication networks are particularly relevant in stem cell biology, …
-
Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… effects and the ability to control cancer stem cells. Cancer Stem Cells (CSCs) are highly tumorigenic cells involved in carcinogenesis and can cause relapses. MicroRNAs (miRNAs) can act as regulators of CSCs, by controlling stemness and invasion. We postulate that PEBP or its polyphenolic …
-
CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly a multifactorial and complex process that includes proliferation, differentiation, …
-
Characterization of lin-42/period transcriptional regulation by the Ikaros/hunchback-family transcription factor ZTF-16 in Caenorhabditis elegans
… 24 hours. Mammalian period also regulates adult stem cell differentiation, although this function is poorly understood. The structure, function and expression of lin-42 are all similar to period. Therefore, we are studying lin-42 regulation and function during C. elegans larval development as a …
-
Comparative studies of brain developmental timing and progression using 3D stem cell models
… brain organoid models, derived from stem cells of different relevant species to establish paradigms for comparative studies in brain development, and understand aspects of human specific brain development in vitro. In order to make fair comparisons between brain organoids of different …
-
Human Liver Organoids as models for investigating drug-induced liver injury
… human in vitro hepatic systems lack the cellular spatial arrangement and hepatocyte functionality observed in vivo. Identification of an in vitro hepatic system capable to reproduce the essential features of the human liver in vivo is thus beneficial to better understand …