Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1370 for “"stem cell"”.
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells …
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Modeling Stem Cell Population Dynamics
… of the stochastic nature of biological systems, mathematical and computational modeling approaches have become more acceptable to experimentalists and clinicians in recent years as contributing to new understandings of complicated cell mechanisms and tissue physiology. Indeed, even single …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs …
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Identification of novel gastric stem cell markers and investigation of Intestinal Stem Cell Cre-mediated Recombination
<p>Very few genetic markers for gastric stem cells are currently described. Identifying new markers is important for increasing our basic understanding of gastric tissues and studying mechanisms of cancer development. Gastric and intestinal tissues share a common developmental program. Thus, …
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Stem cell matrix and cartilage regeneration
… due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been developed for decades and promising results have been observed in clinic. However, the shortage of autologous chondrocytes and their uncertain long-term effectiveness have led …
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Expression Analysis and Stem Cell Engineering
… to develop tools to advance Investigations of stem cells in tissue engineering therapeutics for neurodegenerative disease and spinal cord injury. Two tools to characterize cell fate and a tool to separate a subset of neural cells were developed and evaluated. In the first study, a digital PCR …
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Systems Engineering of Stem Cell Fate
Recent advances in the derivation of functional cells from pluripotent stem cells have raised hope for cell therapy to treat liver ailments. They have enhanced the prospects of developing reliable in vitro models for liver diseases and drug toxicity screening. A differentiation protocol mimicking …
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Survey Attitudes Toward Stem Cell Research
… utilized to assess opinions regarding embryonic stem cell research based on three objectives: willingness to accept stem cells, educational background, and religion. A total of 1 13 fixed-alternative questionnaires were distributed to a diverse group of respondents. Nonprobability sampling using …
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Transcriptional regulators in stem cell biology
Adult stem cells support tissue regeneration by both self-renewing and differentiating into specialized cell types. Analogous self-renewal and differentiation processes enable cancer stem cells to promote tumorigenesis. Transcriptional modulation, enacted by proteins including epigenetic regulators …
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Engineering Organoids for Stem Cell Maturation
… and toxicants. Hepatocytes, or the main liver cell type, perform most of these functions. Typically, primary human hepatocytes (PHHs) are ideal for in vitro liver studies since they are obtained directly from tissues and exhibit adult characteristics and functions. However, sourcing these adult …
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
… are enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. Further characterization of …
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Hematopoietic Stem Cell Threshold Sensing Controls Regulatory Pathways Facilitating Clinically Relevant Ex Vivo Expansion for Stem Cell Transplantation
<p>The ex vivo expansion of hematopoietic stem cells (HSCs) for transplantation has threefold importance: 1.) First, because of the rarity of stem cells there often isn’t a sufficient supply obtainable from common sources for larger children and adults. 2.) Secondly, patient morbidity and time to …
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Extracellular Signalling and Stem Cell Self-Renewal
… and modulating signalling in vitro allows for stem cell populations to be established from these lineages. Fibroblast growth factor (FGF) signalling triggers the differentiation of primitive endoderm (PrE) cells fated to contribute to the yolk sac, while cells unreceptive to FGF form the …
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Identification of Unique Hematopoietic Stem Cell Properties
Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and …
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Molecular Mechanisms in Hematopoietic Stem Cell Aging
The blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to …
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H4K16 acetylation during embryonic stem cell differentiation
… component of the doseage compensation system. It is also unique amongst histone modifications in that it has been directly associated with chromatin decompaction. H4K16ac has been linked to development through its Histone Acetyltransferase, MOF. Deletion of MOF in mice leads to mass …
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Molecular control of embryonic stem cell identity
Embryonic Stem (ES) cells are the in vitro derivatives of the inner cell mass of a developing embryo, and exhibit the property of pluripotency, which is the ability of a cell to give rise to all cell lineages of an organism. Therefore, these cells hold great promise in the treatment of several …
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
… by harnessing the developmental potential of stem cells to restore structure and function to damaged tissues. The recently discovered interdependency of cell phenotype and biophysical environment has created a paradigm shift in cell biology. This dissertation introduces a dynamic in vitro …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… DNA methylation patterns are maintained through cell divisions by maintenance methyltransferase Dnmt1. The exact mechanisms by which these DNA methyltransferase enzymes are targeted to specific genomic regions remain unclear, but may involve interaction with modified histones and/or the …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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