Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"stellate cells"”.
-
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… is to present two approaches to identify Hepatic Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and systematic evolution of ligands by exponential enrichment (SELEX). These HSC-specific ligands can be used for diagnosis and therapy of liver fibrosis. The mechanism …
-
Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… types, and involve mediators presented to the cells in concentrations much higher than physiological values. In addition, the liver lobule contains a 3-dimensional metabolic zonation, and liver cell types comprise a heterogeneous population from the portal triad where the blood flows into the …
-
Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to delineate the role of PGE2 on human pancreatic stellate cells …
-
Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… to cirrhosis is the activation of hepatic stellate cells (HSCs), which secrete extracellular matrix (ECM) proteins such as collagen to form fibrotic scars. Activated HSCs produce vast amounts of fibrotic proteins that require folding and processing prior to secretion. Increased protein …
-
PROGRAMMED ADDICTION OF PANCREATIC CANCER TO NUCLEOTIDE METABOLISM BY THE TUMOR MICROENVIRONMENT
… one of the fastest growing malignancy, yet PDAC cells face a harsh tumor microenvironment (TME) of poor nutrient availability. To adapt, they were shown to exploit stellate cells, the predominant stromal cells, for growth-promoting nutrients. However, there is inadequate understanding of …
-
Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk
Cerebellar stellate cells are interconnected interneurons located in the outer molecular layer. They provide inhibition to Purkinje cells, thereby modulating the final output of the cerebellum. In this work, electrophysiological means were employed to study the stellate cell network at the single …
-
Control of flow and oxygen in a 3-D perfused micro-environment fosters balanced survival of hepatocyte-non-parenchymal cell co-cultures
… However differentiated sinusoidal endothelial cells (SECs), marked by SE-1 expression are difficult to maintain in culture while stellate cells easily activate and over-proliferate. We hypothesized that recreating a liver tissue system that captured in vivo like paracrine influences would …
-
Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… of fibrosis are cancer-associated pancreatic stellate cells (CA-PSCs) who drive disease progression, chemoresistance and metastasis. To survive in the tumour microenvironment, CA-PSCs and PC cells undergo significant metabolic changes. A key alteration is increased expression of nutrient …
-
Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… by simultaneously targeting pancreatic cancer cells and the stroma. In Chapter 1, we briefly introduce the background of the dissertation research and present the Statement of the Problems and Objectives. In Chapter 2, we review the epidemiology of pancreatic cancer and the widely used …
-
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) leads to the reversal of the accumulated extracellular matrix. We therefore hypothesize that targeted delivery of the PCBP2 siRNA to HSCs could potentially treat liver fibrosis. Cholesterol and IGF2R (insulin growth factor 2 …
-
Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
… expansion of IL-17- and IL-22-producing cells in mouse liver during viral infection. We found that a subset of IL-17+ and IL-22+ cells expressed no myeloid/lymphoid lineage markers. Instead, they expressed high levels of stem-like markers, IL-7Rα and RORγt, consistent with the newly …
-
Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
… with non-parenchymal cholangiocytes, endothelial cells, Kupffer cells, and hepatic stellate cells. Disorders affecting hepatocytes are life threatening and increasing in prevalence12, with end-stage treatment relying upon a limited supply of liver donations for transplant. Consequently, the …
-
The role of relaxin in the regulation of human liver and kidney fibrosis
… is portal<br/>hypertension. The hepatic stellate cell is accepted as a major progenitor of liver<br/>myofibroblasts, which have been shown to be a major source of collagen and<br/>extracellular matrix proteins that disrupt liver architecture and function. Relaxin<br/>is a hormone involved …
-
Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss
… out the twinkle gene from astrocytes, glial cells of the brain, causing spongiotic encephalopathy, astrogliosis and ciliogenesis activation in the mouse brain. This model is created by using a glial fibrillary acid (GFAP) promoter, driving a Cre recombinase that together with LoxP sequences …
-
Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… and causes liver dysfunction. Hepatic stellate cells (HSCs) play a major role in hepatic fibrosis. However, the molecular mechanisms remain incompletely understood. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ or WWTR1), key players of the …
-
Insights into the role of hepatic stromal cells and the immune checkpoint protein PD-L1 in liver metastases of pancreatic cancer
… disseminated pancreatic ductal epithelial cells (PDEC) remains unclear. While hepatic stellate cells (HSC) dominate physiological liver contexts, hepatic myofibroblasts (HMF) prevail under inflammation. Despite success in other cancers, PD-1/PD-L1 therapies show limited efficacy in PDAC, …
-
Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… most arise from activated liver-resident hepatic stellate cells (HSCs). There is an increasing number of patients suffering from liver fibrosis in developed countries including the United States, which is anticipated to continue to grow during 2023-2033 period. TGF-β1 is a key cytokine with a …
-
Use of gene expression to characterize heterogeneous liver cell populations
Non-parenchymal cells (NPC's) are integral to recreate the native hepatic microenvironment and necessary to maintain in vivo liver function. A variety of in vitro culture systems have been developed to address different aspects of liver physiology and architecture in order to recreate the …
-
Novel biomarker identification in pancreatic cancer using Raman spectroscopy
… of the interactions between cancer and stellate cells, including the production of SPARC and collagen, in pancreatic cancer. This study concludes by proposing a hypothesis, highlighting the importance of collagen, SPARC and their potential roles in causing biochemical changes to cancer …
Page 1 of 3