Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"stellate cells"”.
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… factor (TGF)-beta is a key mediator of hepatic stellate cell (HSC) activation and extracellular matrix accumulation leading to fibrosis. Aim of the present study was to perturb the TGF-beta pathway in this process by overexpression of Smad7, an intracellular antagonist of TGF-beta signaling. …
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Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… is to present two approaches to identify Hepatic Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and systematic evolution of ligands by exponential enrichment (SELEX). These HSC-specific ligands can be used for diagnosis and therapy of liver fibrosis. The mechanism …
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Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… types, and involve mediators presented to the cells in concentrations much higher than physiological values. In addition, the liver lobule contains a 3-dimensional metabolic zonation, and liver cell types comprise a heterogeneous population from the portal triad where the blood flows into the …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… to cirrhosis is the activation of hepatic stellate cells (HSCs), which secrete extracellular matrix (ECM) proteins such as collagen to form fibrotic scars. Activated HSCs produce vast amounts of fibrotic proteins that require folding and processing prior to secretion. Increased protein …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to delineate the role of PGE2 on human pancreatic stellate cells …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… characterization of endoglin in hepatic stellate cells (HSC). This characterization was performed particularly with regard to the impact and the function of endoglin in the transdifferentiation process of HSC into myofibroblast-like cells (MFB). Transdifferentiation of HSC into MFB plays …
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PROGRAMMED ADDICTION OF PANCREATIC CANCER TO NUCLEOTIDE METABOLISM BY THE TUMOR MICROENVIRONMENT
… one of the fastest growing malignancy, yet PDAC cells face a harsh tumor microenvironment (TME) of poor nutrient availability. To adapt, they were shown to exploit stellate cells, the predominant stromal cells, for growth-promoting nutrients. However, there is inadequate understanding of …
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Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk
Cerebellar stellate cells are interconnected interneurons located in the outer molecular layer. They provide inhibition to Purkinje cells, thereby modulating the final output of the cerebellum. In this work, electrophysiological means were employed to study the stellate cell network at the single …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liver fibrosis …
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Expression, Reinigung und therapeutischer Einsatz eines löslichen TGF-[beta]-Typ-II-Rezeptors in der experimentell induzierten Leberfibrose
… for the transdifferentiation of hepatic stellate cells to myofiborblasts, the key-event of liverfibrosis. The protein may intercept tgf-beta before binding the hepatic stellate cells. For amplification of the protein COS-7 cells were infected with the adenoviral construct …
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Role of monocyte subsets in chronic liver injury and liver fibrosis
… coincides with reduced activation of hepatic stellate cells, less collagen-I accumulation and reduced liver fibrosis in the Ccr2-/- and Ccr2-/-Ccr6-/- mice. Adoptive transfer of WT monocytes into the Ccr2-/-Ccr6-/- or WT animals massively aggravates hepatic fibrosis. Isolated liver-derived …
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Control of flow and oxygen in a 3-D perfused micro-environment fosters balanced survival of hepatocyte-non-parenchymal cell co-cultures
… However differentiated sinusoidal endothelial cells (SECs), marked by SE-1 expression are difficult to maintain in culture while stellate cells easily activate and over-proliferate. We hypothesized that recreating a liver tissue system that captured in vivo like paracrine influences would …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… of fibrosis are cancer-associated pancreatic stellate cells (CA-PSCs) who drive disease progression, chemoresistance and metastasis. To survive in the tumour microenvironment, CA-PSCs and PC cells undergo significant metabolic changes. A key alteration is increased expression of nutrient …
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Kryokonservierung von hepatischen Sternzellen der Ratte
… for the cryopreservation of rat hepatic stellate cells was developed. Isolated HSC of the rat are used as a model of liver fibrogenesis. Many proceedings are studied on this cells, for example the biotransformation, the gene expression, the effect of pharmaceuticals, different kinds of …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… by simultaneously targeting pancreatic cancer cells and the stroma. In Chapter 1, we briefly introduce the background of the dissertation research and present the Statement of the Problems and Objectives. In Chapter 2, we review the epidemiology of pancreatic cancer and the widely used …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) leads to the reversal of the accumulated extracellular matrix. We therefore hypothesize that targeted delivery of the PCBP2 siRNA to HSCs could potentially treat liver fibrosis. Cholesterol and IGF2R (insulin growth factor 2 …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
… expansion of IL-17- and IL-22-producing cells in mouse liver during viral infection. We found that a subset of IL-17+ and IL-22+ cells expressed no myeloid/lymphoid lineage markers. Instead, they expressed high levels of stem-like markers, IL-7Rα and RORγt, consistent with the newly …
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Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
… with non-parenchymal cholangiocytes, endothelial cells, Kupffer cells, and hepatic stellate cells. Disorders affecting hepatocytes are life threatening and increasing in prevalence12, with end-stage treatment relying upon a limited supply of liver donations for transplant. Consequently, the …
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