Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"stellate cell"”.
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… remains the only curative treatment. Hepatic stellate cells (HSCs) play a central role during liver injury and regeneration, driving matrix remodelling and impacting proliferation and differentiation of other hepatic cell types2,3. Traditionally HSCs were considered a homogenous population, …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… this fraction, 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid content …
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Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk
Cerebellar stellate cells are interconnected interneurons located in the outer molecular layer. They provide inhibition to Purkinje cells, thereby modulating the final output of the cerebellum. In this work, electrophysiological means were employed to study the stellate cell network at the single …
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The effects of periodic and non-periodic inputs on the dynamics of a medial entorhinal cortex layer II stellate cell model
… has shown that medial entorhinal cortex layer II stellate cells (SCs) exhibit sub-threshold and firing frequency resonance in the theta frequency band (4 - 10 Hz). In this thesis we seek to understand the biophysical and dynamic mechanism underlying these phenomena and how they are related. We …
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The role of relaxin in the regulation of human liver and kidney fibrosis
… is portal<br/>hypertension. The hepatic stellate cell is accepted as a major progenitor of liver<br/>myofibroblasts, which have been shown to be a major source of collagen and<br/>extracellular matrix proteins that disrupt liver architecture and function. Relaxin<br/>is a hormone involved …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… ligand-binding domain but expressing the intracellular domain. I show that absence of p75 neurotrophin receptor ligand-mediated signals leads to significantly retarded architectural resolution and reduced hepatic myofibroblast loss by apoptosis. Lack of the ligand-competent p75 neurotrophin …
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Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… were associated with lowered hepatic stellate cell activation, a cell type in the liver that when activated begins to lay down scar tissue. Interestingly, the inactive, obese rat may actually have had the greatest capacity to turn over fibrotic tissue but this was not enough to …
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Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… homeostasis require the presence of all liver cell types. In vivo experiments offer only a snapshot of the liver, and usually involve perturbation of normal function through injury or experimental disease. The role of cell-cell interactions in maintaining normal liver function is far less …
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Engineering in vitro models of non-alcoholic fatty liver disease
… (NASH), fibrosis/cirrhosis and hepatocellular carcinoma (HCC). There is no cure for NAFLD or its downstream complications and questions still remain about what factors contribute to disease progression. Specifically, the cause(s) of insulin resistance, lipid accumulation, inflammation, …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with CP have a poor quality of …
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Exploring the interactions between schistosome eggs and the human host
Schistosoma flatworms are a genus of parasitic blood flukes that inhabit tropical and developing communities throughout Africa, Asia and South America. Infection with Schistosoma flukes causes the disease schistosomiasis, which results in approximately 200,000 deaths per year in Sub-Saharan Africa …
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… acid (TCA) cycle is the epicenter of cellular aerobic metabolism and accounts for the majority of cellular ATP production. In addition to its use in anabolic and catabolic processes, TCA cycle intermediates may serve as signaling molecules. The TCA cycle intermediates succinate and …
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Spatially-defined quantitative interleukin 6 (IL-6) detection using polyethylene glycol microgel sensors (μGELISA)
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… (NASH) is defined as lipid accumulation and cellular damage, inflammation and early to modest fibrosis. The progression of NAFLD to NASH remains incompletely understood. Therefore, dissection of mechanisms responsible for progressing this disease is an important area of investigation. In this …
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Effetti di Sorafenib, Imatinib e CORM-A1 in un modello pre-clinico di fibrosi epatica.
… da un eccessivo accumulo di matrice extracellulare all'interno del parenchima epatico ed è basata su complesse interazioni tra le cellule stellate epatiche di Ito responsabili della produzione di collagene e le cellule epatiche residenti. La fibrosi rappresenta una riposta intrinseca a un …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… suppression, likely through inhibition of cancer cell proliferation, extracellular matrix degradation, and epithelial-mesenchymal transition (EMT). The combination treatment notably suppressed cancer stemness, a key factor in tumour initiation, recurrence, and resistance. Subsequently, the …