Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"steatosis."”.
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… is strongly correlated with an increased risk of steatosis, or fatty liver disease, which is caused by a build-up of fat deposits in hepatocytes. All genotypes of HCV appear to cause some degree of steatosis in approximately 50% of infected individuals, especially in the presence of contributing …
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The Association Between Hepatic Steatosis and Glucose Metabolic Dysfunction
… that while excess energy contributes to hepatic steatosis, MCFAs are a primary driver of this condition independent of caloric content, with consequential effects on hepatic glucose metabolism.
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… efflux in two different mouse models of hepatic steatosis. Hepatic steatosis induced by either a high fat diet or enhanced de novo lipogenesis, caused by transgenic overexpression of a constitutively active form of SREBP-1a (SREBP-1a<super>Tg</super>), was associated with a robust induction (up …
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The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] The purpose of this study was to examine the individual and combined effects of exercise and dietary consumption of n3PUFAs as treatments for NAFLD. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were studied due to …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… and biochemical evaluation of hepatic steatosis in pregnancy. To investigate underlying mechanisms, we used qPCR, immunoblotting, and immunofluorescence analysis of tissues from pregnant adiponectin KO and WT mice. Adiponectin KO mice were hyperglycemic, had impaired glucose tolerance …
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Liver Fibrosis and Steatosis in HIV-Infected Patients: Impact of Race/Ethnicity, Gender, BMI, and ART
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… C3A liver cells and oleic acid to induce steatosis. Assessment of the effect of GRT on oleic acid induced steatosis was determined using different concentrations of aspalathin-enriched rooibos (GRT) extract. Cells not exposed to oleic acid were included as controls. Pioglitazone was used …
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Cooperation between peroxisome proliferator activated receptor alpha and delta in regulation of body weight and hepatic steatosis in mice
… significant weight loss and promoted hepatic steatosis in these mouse models. There was time-dependent accumulation of hepatic triglycerides observed in wild-type and in conditionally-expressing hPPARd mice fed a diet containing PPARd synthetic ligand. This was not seen in animals …
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AAV9-mediated (Pro)renin Receptor Antagonism Reduces High Fat Diet Induced Hyperglycemia and Hepatic Steatosis in Mouse Model of Non-alcoholic Fatty Liver Disease
… affecting diet-induced obesity and hepatosteatosis. In this study, we investigated the role of PRR activation in the mechanism of high fat diet (HFD)-induced fatty liver disease using a PRR antagonist, PRO20, in a mouse model of fatty liver disease induced by chronic high fat diet. PRO20 …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
… IT PROTECTIVE IN THE DEVELOPMENT OF HEPATIC STEATOSIS. MICE DEFICIENT IN MKP5 DEVELOPED HEPATIC STEATOSIS, WHICH WAS ASSOCIATED WITH INCREASED P38 MAPK ACTIVITY IN THE LIVER. FURTHERMORE, MKP5 REGULATES THE EXPRESSION OF CIDEA AND FSP27, TWO GENES IMPORTANT FOR THE DEVELOPMENT OF HEPATIC …
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Modulation of Hepatic Lipid Metabolism by Dietary Fats in Neonatal Pigs: Implications for Steatotic Liver Disease
… in SLD. In Study Ia, we demonstrated that steatosis develops as early as day 7 in pigs fed medium-chain fatty acid (MCFA)-rich formulas and rapidly progresses to steatohepatitis by day 14, independent of whole-body adiposity. In Study Ib, we identified a paradoxical metabolic state …
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Hepatic Lipid metabolism in Neonatal Pigs
… high-fat diets of MCFA and LCFA resulted in steatosis from both classes of fatty acids. However, MCFA fed group accumulated 4 more fat in their livers than the LCFA group. Steatosis was accompanied by decreased - oxidation and increased expression of fatty acid synthetic enzymes in MCFA …
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Site and Mechanism of Leptin's Antisteatotic and Insulin Sensitizing Actions in Lipodystrophic Liver
… associated with insulin resistance and hepatic steatosis, which are corrected by leptin administration. This thesis aimed to define the site of leptin action and understand the molecular basis of leptin's insulin sensitizing and antisteatotic effects in lipodystrophy. To determine the site of …
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
… of this thesis are to establish whether hepatic steatosis in itself is sufficient to detrimentally impact myocardial diastolic function, and to investigate mechanisms by which this might occur. In Chapter 3, the association between NAFLD and HFpEF is established in a murine model, demonstrating …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
… general name for conditions ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. End-stage NAFLD cirrhosis carries a substantial risk for early hepatocellular carcinoma development. Therefore, there is an increasing need for new therapeutic approaches for the …
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… such as insulin resistance and hepatic steatosis, a stage within the spectrum of Non-Alcoholic Fatty Liver Disease (NALFD). NAFLD is a common form of chronic liver disease that affects both adults and children. 10-20% of adults have hepatic steatosis, which is characterized by …
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people worldwide. Genotypes (gt) 1 and 3 are the most prevalent, with gt3 HCV being …
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