Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"steatohepatitis"”.
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH is characterized by steatosis, inflammation, cell death, and liver fibrosis and significantly increases the risk of cirrhosis and decompensated liver failure. There are currently no approved drugs on the market for …
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The db mouse as a model for steatohepatitis
… of the liver to an inflammatory condition, steatohepatitis, which may lead onto cirrhosis. Although not associated with alcohol consumption, non-alcoholic steatohepatitis (NASH) has strong associations with obesity, diabetes and dyslipidaemia. Overlapping pathological mechanisms may be …
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Nonalcoholic steatohepatitis (NASH) : animal studies of interactive hepatoxicity
The term "Nonalcoholic steatohepatitis" (NASH) describes a form of liver disease indistinguishable from alcoholic liver disease, but present in persons who consume insignificant amounts of alcohol. The spectrum of non-alcoholic liver disease ranges from non-progressive steatosis, through to NASH and …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… recent data suggest that nonalcoholic steatohepatitis (NASH), the inflammatory phase of NAFLD, is linked to increased cardiovascular risk independent of the broad spectrum of risk factors of metabolic syndrome. Therefore, novel therapies are needed to inhibit the inflammatory liver …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH) are rapidly increasing worldwide in parallel with increasing obesity rates. These obesity-related conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some individuals …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH) are rapidly increasing worldwide in parallel with increasing obesity rates. These obesity-related conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some individuals …
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The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
… and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether they had risk …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH), which is characterized by the induction of hepatocellular death and inflammation, is associated with the activation of cellular stress pathways such as the Unfolded Protein Response (UPR), an adaptive response to disruptions in endoplasmic reticulum (ER) …
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DEVELOPMENT OF IN VITRO NON-ALCOHOLIC STEATOHEPATITIS (NASH) MODEL FOR DRUG TESTING AND PATHOGENESIS STUDIES
Non-alcoholic steatohepatitis (NASH) is a severe chronic fatty liver disease that currently has no effective intervention. Hepatocellular ballooning is one of the key features of NASH diagnosis. Due to their scarcity, it is difficult to study in vivo and isolate for in vitro investigations. How …
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Diversified use of Non-invasive Biomarkers in Study Protocol and Screen failure in Non-Alcoholic Steatohepatitis (NASH)
This study examines how non-invasive biomarkers of NASH are introduced into the study protocol and whether this has an impact on screen failure. The study will investigate the use of non-invasive biomarkers in the design of study protocols for NASH drug trials and will also examine if screening …
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Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis
Non-alcoholic steatohepatitis (NASH), the second phase in liver disease, occurs when adults consume high calorie, high fat diets. Fat accumulated in the liver causes inflammation and irreversible hardening. Grape seed polyphenol (GSP) and d-tocotrienol (d-T3) may have benefits in reducing NASH. We …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
… for conditions ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. End-stage NAFLD cirrhosis carries a substantial risk for early hepatocellular carcinoma development. Therefore, there is an increasing need for new therapeutic approaches for the treatment of this …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
… is the emergence of NAFLD or non-alcoholic steatohepatitis (NASH) with a significant fibrotic disease in developing countries, even in patients of normal or underweight. A critical issue in patients with NAFLD is the differentiation of NASH from simple steatosis (SS). It is then of …
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Modulation of Hepatic Lipid Metabolism by Dietary Fats in Neonatal Pigs: Implications for Steatotic Liver Disease
… (MCFA)-rich formulas and rapidly progresses to steatohepatitis by day 14, independent of whole-body adiposity. In Study Ib, we identified a paradoxical metabolic state characterized by simultaneous upregulation of lipolytic and lipogenic pathways in MCFA-fed pigs, in where increased fatty acid …
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Modulation of Obesity and its Sequelae by Microbiome/Immune System Interactions
… a particular sequelum of obesity, non-alcoholic steatohepatitis. Our data indicate that SFB provides modest protection from the development and maintenance of obesity, but this was mostly evident only in the setting of severe monogenic obesity. Colonization with SFB also exacerbated the …
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Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… range from simple steatosis to the more severe steatohepatitis. Specifically, nonalcoholic steatohepatitis (NASH) has become one of the leading causes for liver transplantation in the United States, and thus clearly become a considerable burden to the U.S. healthcare system.It is not known …
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Predicting Progression of Metabolic Dysfunction-associated Steatotic Liver Disease
… fatty liver to metabolic dysfunction-associated steatohepatitis, a more serious prognosis that can lead to liver failure and death. Additional adverse progressed outcomes include hepatic failure, fibrosis, cirrhosis, and malignant neoplasm of liver and intrahepatic bile ducts. We explore the …
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Using Telemedicine To Optimize The Delivery Of Care In Patients With Liver Disease
… the spectrum of liver diseases, non-alcoholic steatohepatitis (NASH) is the most common cause of cirrhosis and one of the top reasons for a liver transplant. Patients with NASH end up with hepatic decompensation and liver-related complications such as malnutrition, sarcopenia, frailty, and …
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