Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"stearoyl-CoA desaturase"”.
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Identification of Tissue Distribution and Regulation of Bovine Stearoyl-Coa Desaturase by Hormones and Nutrients
… to investigate the tissue distribution of stearoyl-CoA desaturase-1 (SCD) and the regulation of SCD1 protein expression by dietary fat, insulin, polyunsaturated fatty acids (PUFA), and linoleic acid (cis-9, cis-12 18:2). The first study examined tissue distribution of SCD1 protein in …
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Stearoyl-COA Desaturase Gene Transcription, mRNA, And Activity In Response To Trans-Vaccenic Acid And Conjugated Linoleic Acid Isomers
… for lipogenic enzymes, and 3) regulation of stearoyl-CoA desaturase (SCD) gene transcription. In the first study, lactating mice were fed 3% linoleic acid (LA), or 2% LA plus 1% stearic acid (SA), 1% TVA, or 1% CLA mixture. Dietary TVA enriched the 9/11CLA content of carcass, liver, and …
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Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… two most strongly leptin-regulated genes were stearoyl-CoA desaturase-1 (SCD-1) and insulin-like growth factor binding protein-2 (IGFBP-2). SCD-1 was specifically repressed during leptin-mediated weight loss, and mice lacking SCD-1 showed markedly reduced adiposity on both a lean (abJ/abJ) and …
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Elucidation of the Mechanism of Action of a Cell Line Selective Toxin
… metabolized the compounds into irreversible stearoyl CoA desaturase (SCD) inhibitors. SCD has been recognized as a promising biological target in cancer and metabolic disease. However, SCD is essential to sebocytes, and accordingly SCD inhibitors cause skin toxicity. Mouse sebocytes were …
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Genetic engineering oleaginous yeasts for improved lipid production
… production by over-expressing the native acetyl-CoA carboxylase and diacylglycerol acyltransferase genes. Our best strain RT880-AD, derived from IFO0880, was able to produce 16.4±1.1 g/L lipid from 70 g/L glucose and 9.5±1.3 g/L lipid from 70 g/L xylose in shake-flask experiments. Next, in order …
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Conjugated linoleic acid isomers anti-neuroinflammatory effects on activated microglial cells
… impact was associated with an increase in acyl-CoA oxidase 1, an important enzyme involved in the anti-inflammatory peroxisomal beta-oxidation pathway that effectively processes CLA isomers. Importantly, t10,c12-CLA markedly inhibited stearoyl-CoA desaturase 1, which influenced the production of …
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The identification and characterization of two murine genes regulated by the level of dietary fat
… influence of the level of dietary fat on hepatic stearoyl CoA desaturase 1 (Scd1) and Low Fat Mammary 1 (Lfm1) expression and describe the structural organization of the Lfm1 gene. Scd1 and Lfm1 were isolated from a cDNA library constructed from mammary gland tissue of BALB/c mice fed a low fat …
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Site and Mechanism of Leptin's Antisteatotic and Insulin Sensitizing Actions in Lipodystrophic Liver
… that central leptin administration repressed stearoyl-CoA desaturase-1 (SCD-1) mRNA levels and enzymatic activity. We then studied SCD-1 s role in leptin-mediated correction of hepatic steatosis and insulin resistance by generating aP2-nSREBP-1c mice homozygous for SCD-1 deletion. These …
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
… genes SREBP1, fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) were first validated in a bovine mammary epithelial cell line (MacT) and in bovine mammary tissues. At least one or two SRE binding sites in 24 selected lipogenic genes were identified within 50,000 base pair to the …
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Activity and mRNA abundance of enzymes for fatty acid synthesis and desaturation in mammary cell cultures
… CLA at 50 and 100 micromoles inhibited cellular stearoyl-CoA desaturase (SCD) activity and mRNA abundance. However, EA and TVA, when compared with SA, enhanced SCD activity and mRNA abundance at 12.5 and 25 micromoles. In the second experiment 25, 50 or 100 micromoles SA, OA, TVA, LA or CLA were …
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Potentiation of drug-induced cytotoxicity by conjugated linoleic acids (CLA) in in vitro models of drug-resistant cancer
… in the ratio of C18:1/18:0 suggesting the D 9 desaturase enzyme stearoyl-CoA desaturase (SCD) as a potential target for inhibition by fatty acid treatments. The data suggest that CLA-induced changes in ceramide status, intracellular drug accumulation and lipid profiles may underlie the enhanced …
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Characterization of coconut oil and CLA induced lipolysis
… CO-fed mice had greater fatty acid synthase, stearoyl CoA desaturase 1 mRNA expression and less acetyl CoA carboxylase mRNA expression (P<0.01). Sterol regulatory binding protein 1c and malic enzyme expression was least in CO+CLA-fed mice. Study 2: 3T3-L1 cells were differentiated, exposed to …
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Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol
… ratio of 25:1 led to increased expression of stearoyl-CoA desaturase (SCD1) and decreased peroxisome proliferator activated receptor alpha (PPARα) expression at 15:1 and 25:1 (P<0.05), while all ratios showed a significant decrease in the cannabinoid receptor (CB2) expression compared to …
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Alterations in Lipid Metabolism in Mouse Tissues and Hepatic Cell Lines in Response to the Trans10,Cis12-18:2 Isomer of Conjugated Linoleic Acid
… tissue fatty acid profile, mRNA expression for stearoyl-CoA desaturase (SCD) in adipose and liver, and mRNA expression for fatty acid synthase (FAS) in adipose of mice, 2) the effect of a dietary combination of trans-vaccenic acid (TVA) and trans10,cis12-CLA on delta9- desaturation, and 3) the …
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Fatty acid metabolism and SNPs related to obesity in a longitudinal study of Swedish men: Predictors of metabolic syndrome
… nucleotide polymorphisms (SNPs), on the SCD1 (stearoyl-CoA desaturase) gene and SNPs that had previously been associated with body mass index (BMI) or obesity in genome-wide association studies, with variables reflecting metabolic health. The variables reflecting metabolic health were fatty …
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Associations between gene variations and milk composition in New Zealand dairy cattle: A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… Five genes were studied, the diacylglycerol acyl-CoA acyltransferase 1 gene (DGAT1), the fatty acid binding protein 4 gene (FABP4), the stearoyl-CoA desaturase (Δ-9-desaturase) gene (SCD1), the perilipin-2 gene (PLIN2) and the lipin-1 gene (LPIN1). These genes were chosen because they had either …
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Gene variations of FABP4, SCD, GH, and IGF1R and their associations with meat and carcass traits in sheep : A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… genes for fatty acid binding protein 4 (FABP4), stearoyl CoA desaturase (SCD), growth hormone (GH) and insulin-like growth factor 1 receptor (IGF1R) with meat characteristics such as intramuscular fat (IMF) levels, fat percentage, fatty acid profile, and carcass traits. This understanding aims to …
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Effects of dietary fat and protein from corn coproducts on growth, carcass characteristics, ruminal metabolism, and genomic regulation of marbling development in early-weaned beef cattle
… phosphoenolpyruvate carboxykinase 1, and stearoyl-CoA desaturase, as well as, serum leptin concentrations during the finishing phase. Expression of sterol regulatory element binding transcription factor 1 was increased (P < 0.01) at d 112 in steers fed high protein, high fat diets compared …