Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"status epilepticus"”.
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Outcomes of Status Epilepticus in the Elderly
Background: Status epilepticus (SE) is a serious medical condition associated with significant morbidity and mortality. Few studies have addressed this condition in the elderly. The present study examines predictors of SE mortality in this growing population.Methods: SE patients visiting the …
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Non convulsive status epilepticus: ηλεκτροεγκεφαλογραφικά πρότυπα και συσχέτιση με υποκείμενη παθολογία / Non convulsive status epilepticus: electroencephalography patterns and correlation with underlying pathology
Το Non-Convulsive Status Epilepticus (NCSE) αποτελεί μία από τις πιο δύσκολες στη διάγνωση και διαχείριση νευρολογικές καταστάσεις, καθώς δεν συνοδεύεται από μείζονες κινητικές εκδηλώσεις και απαιτεί συστηματική ηλεκτροεγκεφαλογραφική αξιολόγηση. Σκοπός της παρούσας μελέτης ήταν η διερεύνηση των …
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Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
Status epilepticus (SE) describes a state of persistent seizures which are unrelenting. First- line treatment for status epilepticus uses a group of drugs, the benzodiazepines, that promote the action of the major inhibitory neurotransmitter within the brain, gamma (γ)-aminobutyric acid (GABA). In …
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Status Epilepticus Results in a Duration-Dependent Increased Protein Kinase A Activity in the Rat Pilocarpine Model
… changes occurring during the progression of status epilepticus (SE) that could lead to the maintenance of increased membrane excitability. SE was induced by injection of pilocarpine after which rats were monitored both electrographically and behaviorally. After various lengths of time in SE, …
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Demographic and aetiological factors of paediatric status epilepticus at Red Cross War Memorial Children's Hospital: 2016-2018
Background: Status epilepticus is a common medical neurological emergency in childhood which is often serious and life threatening. There is paucity of data with regard to aetiology and demographics of affected children in resource-limited countries. Objective: To describe the demographics and the …
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
Status epilepticus (SE) is a major clinical emergency resulting in continuous seizure activity that can cause brain injury and many molecular and pathophysiologic changes leading to neuronal plasticity. The neuronal plasticity following SE-induced brain injury can initiate epileptogenesis and lead …
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Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
… context of two common neurological pathologies, status epilepticus and traumatic brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and hippocampal homogenates. Upon closer examination, the most profound …
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Cardiac arrest and therapeutic hypothermia: Prognosis and outcome
… strongly correlated to continued coma. A status epilepticus aEEG-pattern carried a poor, but not desolate prognosis. Biochemical neuronal-markers (neuron-specific enolase (NSE) and S-100B) have previously been assessed in non-TH CA patients. In TH, an NSE level of 28 μg/l 48h after CA, or …
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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
… can cause more serious consequences such as status epilepticus and temporal lobe epilepsy, severe life-threatening conditions that often result in death.
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Post-Juvenile Brain Development Modulates Seizure Characteristics and Diazepam Efficacy in the Rat Pilocarpine-SE Model
These studies were completed to examine how status epilpeticus seizure characteristics are modulated during post-juvenile brain development. This may determine if postnatal age in rats is a better identifier of stages of post-juvenile brain development. The first study fully detailed the acute …
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Parental Stress In Tuberous Sclerosis Complex
… features, intractable epilepsy with or without status epilepticus, low adaptive functioning, neuropsychiatric diagnoses (TSC-Associated Neuropsychiatric Disorders; TAND), and parent race and income. These variables accounted for 69% of variability in parent’s PSI scores. Overall, 50% of parents …
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Identification, mechanisms and treatment of perinatal brain injury
… relative sparing of the cortex. Fetuses that had status epilepticus had significantly greater injury than fetuses with discrete seizures alone. There was high mortality due to post-asphyxial hypotension, and i.v. infusion of dopamine, a commonly used inotrope, was ineffective at preventing …
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ANATOMICAL AND ELECTROPHYSIOLOGICAL STUDIES OF AN ANIMAL MODEL OF TEMPORAL LOBE EPILEPSY WITH CLASSIC HIPPOCAMPAL SCLEROSIS
… insufficiently intense to cause convulsive status epilepticus (SE). Two daily 30 minute-long episodes of perforant pathway stimulation in awake Sprague-Dawley rats increased granule cell paired-pulse inhibition and truncated epileptiform discharges evoked during 8 hours of subsequent …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
… the brain. Prolonged epileptic seizure activity, status epilepticus (SE), strongly imposes on the integrity of the delicate brain structure and cell communication. SE not only induces inflammation, but also neuronal death and a transient increase of basal adult neurogenesis in the hippocampal …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… during the initial insult of pilocarpine-induced status epilepticus (SE), and were independent of seizure suppression produced with phenobarbital administration in epileptic rats. Furthermore, time-course studies utilizing these techniques demonstrate that within a week following SE, a widespread …
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Epileptogenesis Causes Long-Term Plasticity Changes in Calbindin D-28k in the Rat Pilocarpine Model of Acquired Epilepsy
… changes were not seen as early as 4 days post-status epilepticus. Western blots quantitated differences between epileptic animals and naive controls. Long lasting decreases in calbindin may play an important role in the altered calcium homeostatic mechanisms observed in epileptic neurons. These …
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Neurofilament light chain
… light chain (NfL) bei Patient*innen mit Status epilepticus. Zu den zentralen Fragestellungen gehörte der Vergleich mit neurologisch gesunden Kontrollen, die Unterscheidung zwischen verschiedenen Statusformen sowie die prognostische Aussagekraft des NfL. Außerdem sollten Aussagen zu der …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… the actions of NRG in chronic TLE we induced status epilepticus (SE) in rats and performed hippocampal brain slice electrophysiology. We discovered that activation of NRG signaling blocks LTP in the sham condition, but enables LTP in epilepsy. This represents a basic alteration in the …
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Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… a seizure that lasts for more than five minutes (status epilepticus) or multiple distinct seizures with incomplete recovery between them (acute repetitive seizures). A patient experiencing a seizure emergency must be treated as quickly as possible to avoid lasting neurological damage and other …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
… seizure (ECS) and Kainic-acid (KA) induced status epilepticus (SE) accompanied by network hyper-excitability. The fifth chapter provides a novel evidence into STEP regulates neuronal intrinsic properties in the hippocampal neurons. In the part of appendix, I describe subcellular …
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