Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 91 for “"statins"”.
-
The potential immunomodulatory effects of the statins in uveitis
… role of the group of compounds known as the statins as adjunctive or steroid-sparing therapy in uveitis. The data recorded provides evidence for the potential of statins in the treatment of uveitis as a steroid-sparing monotherapy or as part of combination therapy.
-
A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
… biosynthesis pathway using pharmacological agent statins, which are reversible inhibitors of HMG†CoA reductase enzyme. The aim of the study was to investigate the role of statins in inducing host protective responses against intracellular pathogens. We report reduced growth of Listeria …
-
Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of Statins
Statins are regular and universal medications for preventing cardiovascular disease and hyperlipidemia. Despite their effectiveness, statin response varies significantly between individuals, which can be attributable to a number of genetic factors and personal medication habits. This thesis aims to …
-
Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis
… of this research was to assess the effects of statins in the prevention of Alzheimer disease.</p><p>Methods: A systematic review of MEDLINE (PubMed) was performed to identify all available published prospective studies that evaluated the effect of statin treatment on the incidence of Alzheimer …
-
IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… linked to CVD and is an important risk factor. Statins – cholesterol lowering drugs- are first choice drugs for reducing the chance of suffering a CVD event. In the USA alone, approximately 32 million individuals take statins. Although randomized control trials of statins have demonstrated their …
-
Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… reductase competitive inhibitors, also known as statins, are widely used agents for lowering cholesterol and reducing the risk for a heart attack. Recent data suggest that statins influence bone metabolic activity by stimulating new bone formation both in vivo and in vitro. Bone resorption in …
-
The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… mechanism of action of the statin is unclear. Statins have been shown to influence MAP kinase pathways in other cell types and, as their modes of action are well established, they can be used to interrogate uncharacterised upstream cell signalling pathways. On this basis, the aims of this study …
-
The economics of a new health technology: an evaluation of the impact of statins on lifestyle behaviors
… changes in diet and exercise behavior. Although statins are highly effective in reducing cardiovascular disease risk, lifestyle improvements can garner significant health benefits in addition to lowering cholesterol. Methods: Grossman's model for the demand of health is applied to inform …
-
Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia
Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke. This paper aims to assess the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients …
-
Farmacijos specialistų žinios ir požiūris į gydymo statinais naudą ir jų sukeliamą nepageidaujamą poveikį /
… and knowledge of pharmacy specialists about the statins. Objectives. 1. To evaluate the knowledge of pharmacy specialists about the benefits and risks of statin use. 2. To evaluate the knowledge of pharmacy specialists about potential interactions of statins with other medications. 3. To …
-
Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… IBC patients taking cholesterol lowering drugs, statins, have improved survival outcomes, and also statins can improve the response to radiation in vitro. Furthermore, statins have been shown to target the cells with stem like-properties called cancer stem cells (CSCs) which are known to be …
-
Do Statins Improve Outcomes in Patients With Asthma on Inhaled Corticosteroid Therapy? A Retrospective Analysis of the Mississippi Medicaid Database 2002-2004.
… benefits of the anti-inflammatory properties of statins in asthma management with contradictory results. Therefore, the objective of this study is to determine if asthma patients on concurrent statin therapy are less likely to have asthma-related hospitalizations and emergency room (ER) visits. …
-
The impact of physical activity on statin-associated skeletal muscle myopathy
BACKGROUND: HMG-CoA reductase inhibitors (statins) are a common and effective pharmacological means of treating hypercholesterolemia and decreasing cardiovascular risk. The most common side effect of statins is skeletal muscle myopathy, which appears to be exacerbated by exercise. PURPOSE: The …
-
The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
… coenzyme A reductase inhibitors (statins) improve endothelial cell (EC) function by enhancing the synthesis of Nitric Oxide (NO) and attenuating the endothelial leucocyte interaction and platelet aggregation. However the effects of statins on endothelial cell proliferation, …
-
The significance of OATP and CYP450 in statin-flavonoid interactions
Statins are the most prescribed drug world-wide as a first-line defence to hypercholesteraemia. In rare cases, statins can have adverse events such as myotoxicity which can further progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between …
-
Chemoprevention in Kidney Cancer
… of three studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based case-control study evaluating the …
-
Studio dell’attività antivirale e/o anti-infiammatoria di nuove molecole di sintesi e/o di farmaci noti
… dr. Bruce Chesebro investigating the effect of statins for the control of neuroinflammation (Part II). Part I - Antiviral activity of quinoxalines derivates as new leads against Picornavirus Aim: New quinoxaline derivatives were synthesized and tested for cytotoxicity and antiviral activity …
-
Impact of Adiposity Status on the Association of Regular Statin Use and Increased Number of Aberrant Crypt Foci
… due to indication bias for prescribing of statins, particularly obesity-induced physiologic dysregulation, might partly explain discrepant results. <strong>METHODS: </strong>We analyzed data from patients receiving standard colonoscopy at the Colon Cancer Prevention Program of the …
Page 1 of 5