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Showing 1 to 20 of 82 for “"statin"”.
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Statin-induced muscle mitochondrial toxicity
Statins are the mainstay of cholesterol-lowering therapy and are taken by millions of people worldwide. These drugs are generally well-tolerated but can cause myopathy ranging from mild muscle pain to fatal rhabdomyolysis. The mechanism of statin-induced myopathy (SIM) is not fully understood and …
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Genetic factors in statin intolerance
… There are approximately 12 million statin users in the United Kingdom. Reports of statin intolerance occurs between 7 and 29% of users, manifesting as muscle ache, fatigue or more seriously, muscle breakdown leading to myopathy. Creatine phosphokinase (CK) levels are used as a …
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The significance of OATP and CYP450 in statin-flavonoid interactions
Statins are the most prescribed drug world-wide as a first-line defence to hypercholesteraemia. In rare cases, statins can have adverse events such as myotoxicity which can further progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between …
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The impact of physical activity on statin-associated skeletal muscle myopathy
BACKGROUND: HMG-CoA reductase inhibitors (statins) are a common and effective pharmacological means of treating hypercholesterolemia and decreasing cardiovascular risk. The most common side effect of statins is skeletal muscle myopathy, which appears to be exacerbated by exercise. PURPOSE: The …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… of GBS.</p><p>Our group previously reported that statins therapeutically attenuate the course of EAN by inhibiting leukocyte migration. This dissertation project was designed to determine the mechanism(s) by which statins attenuate pathological transendothelial migration. We hypothesized that …
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Association of blood lipids, atherosclerosis and statin use with dementia after stroke
… suffer more cardiovascular comorbidities. Statins have been recommended for secondary prevention in stroke patients, but it is unclear whether they have any cognitive effects separate from reducing risk of vascular events. Aim: To triangulate the potential roles of major blood lipids, …
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Statin-associated skeletal muscle damage and its interactions with novel or accustomed exercise
Statin drugs are a very commonly prescribed medication, and their most common side effect is some degree of skeletal muscle myopathy. Unfortunately, this side effect is more likely/severe in statin users who are also exercisers. Purpose: To examine the previously unaddressed interactions of statin …
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Guideline-Directed Statin Therapy in Patients with New or Worsening Symptoms of Peripheral Artery Disease
… be treated with a moderate to high-intensity statin. The extent to which PAD patients with new or worsening claudication symptoms are offered guideline statin therapy is unknown. Methods: In the PORTRAIT registry, patterns of statin therapy were assessed in 1144 patients at 16 PAD specialty …
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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration
… suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the risk of progression to exudative ARMD in a matched case-control study. METHODS: An epidemiological study of 61 cases with …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… health care institutions, in South Africa, simvastatin and atorvastatin are the standard therapy for hypercholesterolemia. In combination with dietary and lifestyle changes statins are the gold standard therapy to effectively reduce LDL levels to lower the risk of cardiovascular disease, e.g. …
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Impact of Adiposity Status on the Association of Regular Statin Use and Increased Number of Aberrant Crypt Foci
… studies consistently show a preventive role of statin use in colon cancer development, evidence from human studies is conflicting with recent reports suggesting an increased risk of aberrant crypt foci and adenoma. We hypothesize that insufficient control of confounding due to indication bias …
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… risk factor for cardiovascular disease (CVD). Statins recognized as LDL-c lowering drugs, have traditionally been the cornerstone in dyslipidaemia treatment and are reported to reduce CVD mortality by 20-30%. However, over the years, the efficacy of statins has been compromised by the emergence …
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Cardiovascular Disease: Prevention and Management
… of morbidity and mortality in the United States. Statins, or HMG-CoA Reductase Inhibitors, are efficacious in reducing major arterial vascular events and also may decrease risk of venous vascular events (venous thromboembolism) in women taking hormone therapy (HT).1–3 However, these drugs have …
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Cost-effectiveness analysis of alternative statin prescribing strategies for the secondary prevention of cardiovascular disease at a South African public sector tertiary hospital
… and are a useful tool for policymakers. Statins reduce the risk of cardiovascular events such as myocardial infarctions and strokes, by lowering low density lipoprotein cholesterol (LDL-C) concentrations. Several studies, mostly conducted in Europe or North America, have demonstrated that …
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Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis
… of this research was to assess the effects of statins in the prevention of Alzheimer disease.</p><p>Methods: A systematic review of MEDLINE (PubMed) was performed to identify all available published prospective studies that evaluated the effect of statin treatment on the incidence of Alzheimer …
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The use of bempedoic acid in treating hypercholesterolemia
Statins are often the first-line therapy in the treatment of patients with hypercholesterolemia. Though often regarded as relatively low risk and widely effective in treating hypercholesterolemia, statin therapy has a variety of limitations, including statin resistance and statin intolerance. These …
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The economics of a new health technology: an evaluation of the impact of statins on lifestyle behaviors
… whether the introduction of cholesterol-lowering statin drugs can be associated with changes in diet and exercise behavior. Although statins are highly effective in reducing cardiovascular disease risk, lifestyle improvements can garner significant health benefits in addition to lowering …
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Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma
… target HMG-CoA reductase (HMGCR) using Fatostatin or Simvastatin effectively restrains the proliferation of B cell lymphoma cells. However, B cell lymphoma cells activate the mTORC1-pS6 pathway in response to statin treatment, suggesting a possible mechanism to counteract statin-induced cell …
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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
Rosuvastatin is commonly prescribed for the treatment of hypercholesterolemia and exerts its effect through targeted accumulation in the liver. Current United States and Canadian dosing guidelines indicate no preference for fed or fasted rosuvastatin administration. In this study, we demonstrate …
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Optimising Cardiovascular Disease Risk Assessment: Application of Dynamic Prediction Tools and Risk Stratification Strategies Using Electronic Health Records
… models have considered effect of post-baseline statin initiation, which may lead to an underestimation of an individual’s future risk of disease. Thus, the second aim is to explore novel approaches to account for post-baseline statin initiation in CVD risk prediction models. Third, a single …
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