Global ETD Search
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Showing 1 to 20 of 192 for “"stat3"”.
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Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
… activation of EGFR, which subsequently activates STAT3 signaling. Furthermore, we demonstrate that IGFBP2 augments the nuclear accumulation of EGFR to potentiate STAT3 transactivation activities, via activation of the nuclear EGFR signaling pathway. Nuclear IGFBP2 directly influences the invasive …
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STAT3-protein interactions in IL-6/gp130 signaling
… Transducer and Activator of Transcription 3 (STAT3) is a central transcription factor downstream of IL-6/gp130 signaling. This thesis investigates how STAT3 regulates IL-6 signal transduction by interacting with its coactivators. First, the function of an IL-6 inducible complex of STAT3 with …
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Role of Stat3 In Human Nk Cell Functions
… IL-21 (mbIL-21), which predominantly activates STAT3, induce robust expansion and activation of human NK cells. Further investigations revealed role of STAT3 in the transcriptional regulation of NKG2D, a primary activating NK receptor. Based on these findings, I hypothesized that STAT3 signaling …
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Activation of HGF/Met Signaling Induces Delayed STAT3 Phosphorylation
… study, we observed delayed phosphorylation of STAT3 by activation of HGF-Met signaling in Sm Met transfected cells and Chang cells. NIH3T3 cell line was transfected with Trk-Met^(sm) and Trk-Metsm to exclude the effects of endogenous HGF and Met. The phosphorylation of STAT3 following treatment …
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Instructing naïve pluripotency ; JAK/STAT3 and Nanog in reprogramming
Reprogramming of somatic cells to pluripotency is a topic of extensive research driven by the potential of induced pluripotent cells in in vitro disease modelling, drug screening and regenerative medicine. The pluripotency associated transcription factor Nanog has been subject to a lot of …
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Analysis of NFI-X3 and STAT3 Interaction and Its Functions
… by two transcription factors, NFI-X3 and STAT3, which form a complex with each other (Singh et al., 2011). Here, we show that the N-terminal domain of NFI-X3 is sufficient and required for its interaction with STAT3. We also show that the DNA-binding domain of NFI-X3 is required to induce …
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Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… protection against bacterial pathogens requires STAT3 activation. We hypothesize here that STAT3 activation is also required for Pam2ODN-induced protection against the influenza A virus (IAV).</p> <p> In our in-vitro model, human bronchial epithelial cells (HBEC3-kt) were treated with STAT3 …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… In the present study, we examined the impact of Stat3 deletion or activation on behavior of keratinocytes, including keratinocyte stem cells (KSCs). Deletion of Stat3 specifically in the bulge region of the hair follicle using K15.CrePR1 X Stat3<sup>fl/fl </sup>mice led to decreased tumor …
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Lgr5 Regulation of Stat3 Signaling and Drug Resistance In Colorectal Cancer
<p>LGR5 Regulation of STAT3 Signaling and Drug Resistance in Colorectal Cancer</p> <p><em>Tressie Alexandra Capri Posey </em>B.S.</p> <p>Advisory Professor: Kendra Carmon, Ph.D.</p> <p>The greatest difficulty in treating colorectal cancer (CRC) is the development of drug resistance which leads to …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… infection remains poorly understood. Notably, STAT3, a highly immunomodulatory and pro-survival factor, interacts with the E. chaffeensis effector protein TRP75. Additionally, TRP75 contains predicted SLiMs which could mediate interfaces with SH2 and SH3 domains, interaction modules important …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… Transducer and Activator of Transcription 3 (STAT3) mediates the intracellular signaling of interleukin 10 (IL-10), an immunosuppressive cytokine. Therefore, we hypothesized that STAT3 and IL-10 inhibit cDC1 function and induction of T cell-mediated immunity. Herein, we show that IL-10 …
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Μελέτη μιας νέας μετάλλαξης στο γονίδιο STAT3 που ενέχεται στο σύνδρομο ανοσοανεπάρκειας Hyper-IgE
… ετερόζυγες μεταλλάξεις στον μετγραφικό παράγοντα STAT3, ευθύνονται για την αυτοσωμική επικρατούσα μορφή του HIES. Στην παρούσα ερευνητική εργασία ταυτοποιήθηκε και χαρακτηρίστηκε μια νέα μετάλλαξη στην περιοχή δέσμευση του DNA (DNA-binding domain) του μεταγραφικού παράγοντα STAT3 σε έναν ασθενή με …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… employed to measure the effects of IL-10 and STAT3 expression on cell viability, proliferation, and differentiation. Bax-deficient and Bcl-2 transgenic bone marrow cells were used to determine the importance of the mitochondria in IL-10-mediated effects.Overview. Mast cells arise from …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… was previously demonstrated to require the STAT3 transcription factor (signal transducer and activator of transcription 3), the principal signaling molecule activated upon G-CSF-binding of its receptor, but the mechanism was unknown. The chemokines KC (Cxcl1) and MIP-2 (Cxcl2), and their …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… to primarily activate the transcription factor STAT3, which has been shown to be necessary for ThI7 differentiation. Numerous cytokines activate STAT3, but IL-6 is the most potent inducer of TH17 cells, so we sought to find out what is special about IL-6's induction of STAT3. In the first of …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
<p>Investigating the roles of lung epithelial STAT3 in therapeutically inducible resistance to acute bacterial pneumonia.</p> <p>Vikram Vitthal Kulkarni, M.S.</p> <p>Advisory Professor: Scott Evans, MD.</p> <p>The lung epithelium is a dynamic tissue capable of displaying structural and functional …
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Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… It is associated with mutations in STAT3, which disrupt protein domains responsible for transcriptional function. Patients with HIES display osteoporosis and enhanced inflammatory cytokine production similar to hematopoietic Stat3-deficient mice. Since osteoclast and inflammatory …
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Overcoming Resistance to CDK4/6-targeted Therapy Using JAK2/STAT3 Inhibitor in Triple-Negative Breast Cancer
… transducer and activation of transcription 3 (STAT3) signaling pathway is significantly correlated with CDK4/6i resistance signature in breast cancer, and its co-activation with CDK4/6 pathway is significantly enriched in TNBC patients. Together with the consistent <em>in vitro</em> and <em>in …
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