Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"starvation response"”.
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Starvation Response in Caenorhabditis elegans
… behavioral changes so as to cope with nutrient starvation. Although starvation response is essential for the survival of animals during nutrient deprivation, uncontrolled or uncoordinated starvation responses could be harmful. Autophagy, a lysosomal degradation pathway for long-lived proteins …
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The Unconventional Amino Acid Starvation Response of the Malaria Parasite, Plasmodium falciparum
… how P. falciparum responds to isoleucine starvation, we monitored parasite growth in isoleucine-limiting conditions. We observed that in vitro parasite growth is notably slower in medium containing low concentrations of isoleucine, but completion of the life cycle, consisting of steady …
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The Role of CcpA in Regulating the Carbon-Starvation Response of Clostridium perfringens
… toxins. This work expands the knowledge of the starvation-response of C. perfringens, which includes several potential virulence factors, sporulation, motility and biofilm formation. Sporulation protects cells from a variety of stresses, including starvation. Efficient sporulation requires the …
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Prochlorococcus genetic transformation and genomics of nitrogen metabolism
… in ambient nitrogen. We characterized the N-starvation response of Prochlorococcus MED4 and MIT9313 by quantifying changes in global mRNA expression, chlorophyll fluorescence, and Fv/Fm along a time-series of increasing N starvation. In addition to efficiently scavenging ambient nitrogen, …
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Analysis and productivity improvement of an automated material handling system through simulation
… explores two routing heuristics designed around starvation response and dynamic capacity analysis, which simulation suggest may yield a 6.73% increase in throughput. In doing so, the thesis provides a case study on process improvement using simulation to characterize a complicated mechanical …
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Characterization of The Rna Binding and Rna Degrading Subunits of The Eukaryotic Exosome
… for the exosome and that in its absence the iron starvation response of the cell is activated.</p> <p>Despite numerous studies of the exosome, only a few address the physiological relevance of the catalytic activity. This work shows that the exonuclease of the exosome is important for oxidative …
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Phenotypic Analysis of the Regulatory Role of the Leucine-Responsive Regulatory Protein (LrpPA) in Pseudomonas aeruginosa
… of virulence factors that are a part of the starvation response and are important in host-pathogen interactions. Additionally, <em>P. aeruginosa</em> is resistant to a large number of antibiotics and has become difficult to treat once it has colonized a tissue. New pharmaceutical treatments …
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Inositol Pyrophosphate Phosphatases as Key Enzymes to Understand and Manipulate Phosphate Sensing in Plants
… plants utilize a network of characterized responses known as the Phosphate Starvation Response (PSR) to remobilize internal stores of P as well as external P from soil. Emerging evidence shows the PSR is regulated by a specialized group of secondary messenger molecules, inositol …
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CHARACTERIZING THE ROLE OF PUTATIVE VIRULENCE GENES ASSOCIATED WITH INFECTION, COLONIZATION AND PERSISTENCE OF SALMONELLA ENTERITIDIS IN CHICKEN USING A BIOLUMINESCENT REPORTER
… the data suggested that chickens mount an iron starvation response towards SEn. To detect an iron starvation response during gastrointestinal colonization, a biosensor for iron limitation was introduced. The photonic signal strength increased towards the 48-hour post-infection during cecal …
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Nla28 Activator Modulates σ54-dependent Gene Regulation in Myxococcus xanthus
… developmental processes in bacteria. In response to environmental changes, M. xanthus cells collectively and dramatically adjust their morphology, physiological functions, and biosynthesis. Particularly, M. xanthus copes with starvation by producing fruiting bodies filled with dormant and …
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Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
… longer timescales, animals require physiological responses to tolerate variation in food availability. Most of our mechanistic knowledge of these processes comes from terrestrial mammals and insects, while there are major knowledge gaps for marine invertebrates. My dissertation focuses on the …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… coordinate these physiological and behavioral responses to starvation. The liver-derived endocrine hormone fibroblast growth factor 21 (FGF21) is induced in chronic fasting and acts as a global starvation signal. Previous studies focusing on FGF21 as an anti-diabetic drug indicate that FGF21 …
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Regulation of yeast development by mRNA methylation
… two distinct phases: an early stage of initial starvation followed by a commitment to differentiation. Cells that are in the initial starvation phase revert to yeast-form mitotic growth if shifted to nutrientrich conditions. Cells that are in the commitment to differentiation phase are incapable …
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Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
… longer timescales, animals require physiological responses to tolerate variation in food availability. Most of our mechanistic knowledge of these processes comes from terrestrial mammals and insects, while there are major knowledge gaps for marine invertebrates. My dissertation focuses on the …
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Elucidating the function of inositol pyrophosphate signaling pathways in Arabidopsis thaliana
… to leverage available Pi, known as the Phosphate Starvation Response (PSR). The inositol phosphate (InsP) signaling pathway is a crucial element of the plant's ability to regulate the PSR and respond to changing energy conditions. InsPs are synthesized from the cyclic 6-carbon polyol scaffold, …
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Identifying the Role of DAP-1 and H3.3 Histones in Starvation and Longevity in <i>Caenorhabditis Elegans</i>
… of food; especially during periods of starvation viability has to be maintained. At the same time, a growing body of evidence suggests that transient or intermittent starvation is beneficial for healthy ageing, and indeed leads to increased lifespan. This has been demonstrated in model …
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Mathematical Model of the Cell Cycle Control and Asymmetry Development in Caulobacter crescentus
… differentiation, signalling transduction, stress response, and asymmetry development of prokaryotes. The dimorphic cell cycle of Caulobacter is driven by the elaborate spatiotemporal organization of regulatory molecules through regulations of synthesis, degradation, phosphorelay, and localization. …
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Harnessing the genetic potential for arbuscular mycorrhizal symbiosis in rice
… limited by the variable nature of plant host response, particularly mycorrhizal growth responsiveness (MGR) (Hetrick et al., 1992; Lehnert et al., 2018; Taylor et al., 2015; Thirkell et al., 2022; Xavier & Germida, 1998). Here, in collaboration with the International Rice Research Institute …
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Investigating the genomic, transcriptomic and metabolic landscape of Chlamydomonas reinhardtii in the context of vitamin B12 availability
… carbon cycle related metabolite alterations in response to vitamin B12 scarcity in a B12 auxotroph and its B12-independent progenitor of C. reinhardtii and characterise common strategies eukaryotic cells use to cope with low B12. Findings highlight that the “B12-specific response” includes …