Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"stalled replication forks"”.
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Flap Endonuclease 1 ensures telomere replication and stability
… are integral to genomic stability. High fidelity replication of telomeres is indispensable for their stability. Telomere replication is a challenging task that is completed through the coordinated actions of telomere binding proteins and DNA replication and repair proteins in ways that are not …
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Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia
… homologous recombination repair of gemcitabine-stalled replication forks as a potential mechanism contributing to resistance. We also studied the effect of hyperthermia on homologous recombination pathway to explain the previously reported synergy between gemcitabine and hyperthermia. We found …
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Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication
… These abnormalities may result from a defect in replication restart at damaged or stalled replication forks. Thus, whereas dnaBS3 71P suppresses the defects of mutant cells that cannot initiate or restart replication, expressing DnaBS371P in wild-type cells causes defects in initiation and …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… present barriers to DNA replication that, when not properly resolved, lead to replication fork stalling and collapse and genomic instability.</p> <p>DNA damage and replication stress trigger signaling cascades potentiated by multiple types of post-translational …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… response to DNA damaging agents, and DNA replication stress mitigation respectively. More specifically, we find HORMAD1 is critical for protecting stalled DNA replication forks in LUAD. Loss of HORMAD1 leads to nascent DNA degradation, an event which is mediated by the MRE11-DNA2-BLM …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… resistance, and poor prognosis. During replication stress, the replication fork stalls and forms a reversed fork which may be degraded by several DNA nucleases. At the stalled fork, genome stability is maintained by fork end protection and subsequent restart of the replication. Abro1 has …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
… marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated that disruption of DNA replication, known as replication stress, can expand the cell fate of mouse embryonic stem cells (mESCs) by activating totipotency and …
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The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
DNA replication is continually impeded by endogenous lesions that cause the stalling of replication forks. If left unchecked, this threatens the integrity of the genome and may be a driver of cancer development. Utilizing the <italic>Mcm4<super>chaos3</super></italic> mouse model, we found that …
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Mechanisms of Palindrome-Mediated Chromosomal Instability
… bp or less form stable hairpins which can block replication, and these hairpins are cleaved by the Mre11/Rad50/Xrs2/Sae2 complex. In contrast, palindromic sequences with spacers longer than 8 bp are not cleaved by MRX/Sae2 and do not block replication fork progression. I show that these effects …
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Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair
… of spontaneous DNA lesions or collapse of stalled replication forks. The RecQ helicases are a family of helicases known to aid in the repair of these DSBs and help maintain genomic stability and integrity. WRN and BLM are helicases in the RecQ helicase family. Mutations in the genes for …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
… that participates in error-free repair of stalled replication forks. HLTF was found degraded very early during infection, and its expression remained low throughout the course of HCMV lytic cycle. De novo expression of UL145, a previously uncharacterized viral protein, was found necessary …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… gene, RAD21, in mitigating EWS-FLI1-induced replication stress and promoting oncogenesis. We find that the overexpression of RAD21 facilitates the resolution of transcription-replication conflicts in EWS-FLI1 expressing cells. This is achieved partially by RAD21’s recruitment to the stalled …
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Investigating the DNA damage response induced by Typhoid Toxin
… DNA (ssDNA) occurring mainly in S phase due to stalled replication forks. The ssDNA sensor RPA binds to ssDNA to activate the ATR pathway marked by phosphorylation of ATR substrates H2AX, CHK1 and RPA itself. This study found that typhoid toxin induces a canonical DDR with γH2AX accumulating in …
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Mechanisms underlying genome maintenance and tumour suppression by BRCA2
… processes including homologous recombination, replication stress tolerance, maintenance of the G2 and spindle assembly checkpoints, and in completion of cytokinesis. Much evidence suggests that BRCA2 acts as a tumour suppressor by maintaining genome integrity through its functions during DNA …
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Untersuchungen zur Rolle des <i>MPH1</i>-Gens aus <i>Saccharomyces cerevisiae</i> bei der Reinitiation der Replikation nach schadensinduzierten Arresten
Um Läsionen aus der DNA entfernen zu können, machen sich Reparaturmechanismen wie Nukleotid- oder Basenexcisionsreparatur, mismatch-Reparatur etc. die Tatsache zu Nutze, daß die Information auf beiden Strängen vorhanden ist. Der geschädigte Bereich wird ausgeschnitten und die entstehende Lücke mit …