Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"stalled replication fork"”.
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… resistance, and poor prognosis. During replication stress, the replication fork stalls and forms a reversed fork which may be degraded by several DNA nucleases. At the stalled fork, genome stability is maintained by fork end protection and subsequent restart of the replication. Abro1 has …
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Genetic analysis of longevity in Saccharomyces cerevisiae
… ribosomal DNA (rDNA) caused by the presence of a stalled replication fork. Mutation of the replication fork block protein Foblp dramatically reduces ERCs and extends life span. A central regulator of longevity in yeast is the silencing protein Sir2p. Deletion of SIR2 shortens life span and …
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Single-molecule study of the DNA helicase regulating genomic stability
… various cellular functions including plasmid replication and counteracting deleterious recombination. Using single molecule FRET technique and site-directed mutation, we discovered enzymes new activity: PcrA act as a powerful motor and remove RecA protein effectively from single strand DNA …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… gene, RAD21, in mitigating EWS-FLI1-induced replication stress and promoting oncogenesis. We find that the overexpression of RAD21 facilitates the resolution of transcription-replication conflicts in EWS-FLI1 expressing cells. This is achieved partially by RAD21’s recruitment to the stalled …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… present barriers to DNA replication that, when not properly resolved, lead to replication fork stalling and collapse and genomic instability.</p> <p>DNA damage and replication stress trigger signaling cascades potentiated by multiple types of post-translational …
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DDI1/2 and RTF2-Dependent Regulation of RNASE H2 at the Replisome Ensures Genome Stability
… DNA Damage Inducible 2 (DDI2), are active in the replication stress response (Kottemann et al., 2018). Under conditions of replication stress, DDI1/2 function to remove Replication Termination Factor 2 (RTF2) from the replisome. Persistence of RTF2 at the replisome compromises the replication …
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Role of WD domain-containing proteins in cell cycle progression
… complex, Origin Recognition Complex (ORC), onto replication origins on the chromosome. The loading of ORC triggers the assembly of the pre-replicative complex (pre-RC) at origins, which licensed the origins prior to entering S phase. Unlike yeast, replication origins in higher eukaryotes do not …
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
Das MPH1-Gen aus Saccharomyces cerevisiae kodiert für eine DNA-Helikase, die an der nicht-fehlerbehafteten Überbrückung von DNA-Lesionen durch homologe Rekombination beteiligt ist. Simultane Deletion der Gene MPH1 und SRS2 - das ebenfalls für eine DNA-Helikase kodiert - resultiert im …
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Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia
… homologous recombination repair of gemcitabine-stalled replication forks as a potential mechanism contributing to resistance. We also studied the effect of hyperthermia on homologous recombination pathway to explain the previously reported synergy between gemcitabine and hyperthermia. We found …