Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"stable isotope tracing"”.
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In vivo 13C stable isotope tracing of single leaf development in the cold
… measurements is the in vivo integration of a stable or radioactive label into a plant without perturbation of the system. To follow the carbon flow of a precursor metabolite, a method is developed in this work that is based on metabolite profiling of primary metabolites measured with a mass …
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
… PCa cells and CRPC tumors. Stable isotope tracing studies suggest that this enhanced glutamine metabolism drives an antioxidant program that allows these cells to tolerate higher basal levels of ROS. Inhibition of glutamine metabolism with either a small-molecule glutaminase …
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LAND USE LEGACY REGULATES MICROBIAL COMMUNITY STRUCTURE AND FUNCTION IN TRANSPLANTED CHERNOZEMS
… varied among transplanted soils. A 13C stable isotope tracing experiment determined that community composition and function of active cellulose decomposers was different among soils indicating that the subset of the whole soil communities that was active also remained different between …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
… Metabolite profiling coupled with stable isotope tracing of highly metastatic colorectal cancer cells revealed that PCK1 reversed the TCA cycle under hypoxia to repurpose aspartate, a TCA cycle product, as a precursor of pyrimidines to promote hypoxic cell growth. On the other hand, …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
… the CD8+TILs' functional impairment. Using 13C-stable isotope tracing in vivo, I show that metabolically stressed CD8+TILs in late stage tumors increasingly depend on fatty acids (FAs) catabolism for energy production. Promoting FA catabolism by CD8+TILs improves their effector functions and …
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Tracing carbon flows through Arctic and alpine watersheds
… dwarf shrub—with glucose, and employed stable isotope tracing to quantify substrate conversion to CO2, incorporation in microbial biomass, and retention in bulk soil. We measured responses during peak biomass, fall senescence, and spring thaw to assess interactive effects of glucose …