Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"squamous epithelium"”.
-
Factors Influencing the Somatic Mutational Landscape of Ageing Squamous Epithelium
… by keratinocyte skin cancers and oesophageal squamous cell carcinoma, which both develop from squamous epithelium, yet are remodelled during ageing by very different mutagenic processes and environmental exposures. In this thesis, I investigate the influence of cancer risk factors on the …
-
Migration of human tympanic epithelium in health and disease
… masse</i> migration of keratinised stratified squamous epithelium across the external surface of the human ear drum is an essential function in the maintenance of this delicate membrane by removing dead squamous epithelium to the external meatus for dispersal. The abnormal presence of the same …
-
The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster
… for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it is easily accessible and can be everted simply, facilitating macroscopic …
-
Gross and Microscopic Observations on the Lingual Structure of the West Indian Manatee (Trichechus manatus latirostris)
… dorsum to be covered with a thick stratified squamous epithelium. The caudal dorsal and lateral open pits led to well-developed mucous salivary glands. Foliate papillae, located on the caudal region of the tongue, contained taste buds embedded in the epidermis. Glands within the foliate …
-
The Columnar Lined Esophagus: aspects on the assessment of dysplasia and on the relationship with the esophageal submucosal glands
Columnar metaplasia, where columnar epithelium replaces the normal squamous epithelium in esophagus, is considered to be a precancerous condition in which the development of adenocarcinoma can be followed through various grades of dysplasia. The interpretation of these histological changes is …
-
The Role of Cervical Reserve Cells in Epithelial Regeneration and Homeostasis in the Murine and Human Cervix
How cervical epithelium maintains homeostasis and repair, and how the high-risk human papilloma viruses (HR-HPV) drive neoplasia at the cervical transformation zone (TZ) has been poorly researched. The cervical TZ is thought to be a stem cell niche as it harbours a unique cell population called …
-
Exploring the role of BCL11A in the oesophagus and mammary gland using in vivo lineage tracing and 3D organoid models.
… BCL11A as a selectively upregulated gene lung squamous carcinoma (LUSC)3 and some preliminary data suggest that it is also upregulated in oesophageal squamous carcinoma (OSCC). With proven roles in malignancy and little knowledge about its physiological function, this work reports the combined …
-
Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
… each year, approximately 90% of which are squamous cell carcinomas (SCCs). Over half of all HPV-positive cervical SCCs are caused by the deregulated expression of HPV16 oncogenes E6 and E7 in proliferating basal cells of the cervical squamous epithelium. The major risk factor associated …
-
RegulationofGap Junction Protein,Connexins in Immortalized Human Keratinocytes Cells(HaCaTcells)
… is characterized by the presence of a squamous epithelium invading in the middle ear cavity, and is one of the most prevalent forms of otological diseases. The histologic features of cholesteatomas are similar to hyperproliferation and hyperkeratosis of the skin. The mechanism of …
-
Investigating mitochondria alterations in esophageal pathologies
Esophageal squamous epithelium possesses a defined proliferation-differentiation gradient essential for barrier function, the primary defense against luminal contents such as food allergens and carcinogens. This barrier is perturbed in esophageal diseases, including eosinophilic esophagitis (EoE), …
-
Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus
… The majority of these carcinomas are squamous cell carcinomas and are associated with high risk-HPV infection. HIV infection appears to interact synergistically with high risk-HPV in the development of squamous cell carcinoma at this site. Aims and objectives: To review the pathology …
-
Emydomyces testavorans infection in aquatic chelonians
… lesions are characterized by ulceration and squamous metaplasia of the keratinized scute epidermis, necrosis and destruction of the underlying shell bone, and formation of epithelial inclusion cysts within the dermis and bone. These cysts are lined by keratinizing stratified squamous …