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Showing 1 to 6 of 6 for “"squalene synthase"”.
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Three genes from Solanum chacoense coding for squalene synthase
Squalene synthase (EC 2.5.1.2.1; SQS) is located at a branch point in the isoprenoid pathway and catalyzes the condensation of two molecules of farnesyl diphosphate to form squalene. SQS activity contributes to the formation of triterpenes and sterols, including phytosterols, brassinosteroids, …
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Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors
… diphosphate and methanediphosphonates towards squalene synthase compared to the analogous acyclic azabifarnesyl diphosphate may indicate a bridged non-classical, protonated cyclopropane intermediate in the formation of presqualene diphosphate.
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Biosynthesis of Steroidal Glycoakaloids in Solanum chacoense Bitter
… on sterol / SGA biosynthesis have implicated squalene synthase as a key regulatory enzyme because it catalyzes an irreversible step from the mevalonic acid pathway. However, the regulatory mechanisms of squalene synthase are not yet known. A study was conducted to elucidate the distribution …
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Characterization of Host Plant Defense Responses to Parasitization by <I>Orobanche aegyptiaca</I>
… yet repressed in response to pathogen elicitors (squalene synthase). Genes analyzed that are associated with systemic defense include <I>PR-1</I>, <I>PR-2</I>, and <I>PR-5</I>, all of which are induced in response to pathogen attack as part of the systemic acquired resistance (SAR) response. Plant …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… pathway that is normally converted mainly to squalene by squalene synthase in the first committed step of sterol biosynthesis. Treatment with the squalene synthase inhibitor squalestatin 1 (SQ1) causes accumulation of FPP, its dephosphorylated metabolite farnesol, and several oxidized …
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Head-to-head terpene synthases: Mechanism of action and inhibition
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. In this work, I used x-ray crystallography, and mutagenesis to study the …