Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"spotted fever"”.
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The role of dendritic cells in rickettsial infection; initation of early immunity to spotted fever group Rickettsiae
Identifying the role(s) dendritic cells play in rickettsial infection is important in determining the characteristics which elicit protective immunity. Previous data imply that Th1 responses are essential for immunity to rickettsiae; however, they do not address mechanisms important in initiating …
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Identification of protective rickettsial antigens for vaccine development
… and cross-protective immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens and correlates of protective cellular immunity are critical steps towards vaccine development …
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Genetic Structure of Amblyomma Cajennense (Acari: Ixodidae) Populations Based on Mitochondrial Gene Sequences
… This tick is a vector of the agent of Brazilian spotted fever, an often fatal disease in South America. Throughout its geographic range, populations of A. cajennense have shown differences in ecological adaptation while feeding on a variety of hosts ranging from livestock, birds, and humans. In …
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The Lyme Disease Spirochete, <i>Borrelia burgdorferi</i>, in Tick Species Collected from Raccoons (<i>Procyon lotor</i>) and Opossums (<i>Didelphis virginiana</i>) Trapped in the Warren and Barren Counties of South Central Kentucky
… zoonoses such as Ehrlichiosis, Rocky Mountain Spotted Fever, and Lyme disease has steadily increased in the southeastern United States in recent years. According to the Centers for Disease Control and Prevention (CDC), the southeastern states accounted for 1,200 of the 27,000 total cases of …
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Characterization of the Bacterial Microbiome of Exotic Tick Species Collected from Migratory Birds
… genus level was found in <em>Ixodes</em> genera. Spotted fever group rickettsiae were detected in samples of <em>Amblyomma sabanerae</em> and <em>Amblyomma maculatum</em>. These findings provide an insight into the bacterial communities residing within the tick species parasitizing migratory …
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Role of c-Cbl in Invasion of Mammalian Cells by Rickettsia Conorii
… bacterium that causes Mediterranean spotted fever. R. conorii is transmitted from ticks to humans and invades vascular endothelial cells. A recent publication (Martinez et al., 2005) has identified Ku70 as a host cell receptor that binds to rOmpB, an R. conorii surface ligand. The …
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An Insight Into the Microbial Diversity and Expression of Cysteine Protease Inhibitors (Cystatin) in <i>Rickettsia parkeri</i> Infected <i>Amblyomma maculatum</i>
… In this study, we investigated the spotted fever group of rickettsial diversity in <em>A. maculatum</em> based on rickettsial <em>ompA</em> gene PCR. Our results showed <em>A. maculatum </em>harbors <em>R. parkeri, R. amblyommii, </em>and <em>R. endosymbiont of A. maculatum.</em> …
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Characterization of rickettsial infection dynamics within Dermacentor variabilis and Amblyomma maculatum
Spotted fever group (SFG) Rickettsia are primarily associated with their reservoir host and vector, the tick. Rickettsial colonization and maintenance within the arthropod is a key component of vector competence and pathogen transmission to the mammalian host. Contemporary detection of novel tick …
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Identification and Characterization of a Relish-type NF-kB, DvRelish in Dermacentor variabilis, the American Dog Tick
… and parasites. Pathogenic and non-pathogenic Spotted fever group (SFG) Rickettsia are maintained and transmitted by ticks with specific hard tick-Rickettsia pairings evident in nature. The pathogenic SFG Rickettsia rickettsii is transmitted by the hard tick Dermacentor variabilis. In response …
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The tick response to Rickettsial dissemination during typical and atypical Rickettsial infection
Ticks are the only disease vectors for spotted fever group (SFG) Rickettsia which are obligate intracellular bacteria belonging to the genus Rickettsia. In nature, ticks maintain the infection of SFG Rickettsia via vertical and horizontal transmission. However, the prevalence of rickettsial …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… infections in man including Rocky Mountain spotted fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased microvascular permeability, the mechanisms of which are completely unknown. We sought to determine the impact of host responses to …
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Tick abundance and microorganism diversity in the 11 counties comprising the Choctaw Nation of Oklahoma
… exhibited some of the highest reported rates of Spotted Fever Rickettsiosis and Ehrlichiosis within humans in the United States. However, the lack of localized surveys of tick vectors in the region have left gaps in our understanding of these diseases in the region. This study attempts to define …
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Determining the Prevalence and Distribution of Tick-Borne Pathogens in Southeastern Virginia and Exploring the Transmission Dynamics of Rickettsia Parkeri in Amblyomma Maculatum
… In the United States, cases of Lyme disease, spotted fever rickettsioses, ehrlichiosis and anaplasmosis are on the rise. Factors related to emergence include appearance of a new pathogen, recognition of an existing pathogen and environmental changes that result in new exposure events. Despite …
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High resolution modeling of tick density and detection of Rickettsia spp. in Dermacentor spp. ticks at Turnbull National Wildlife Refuge, WA
… rickettsii, which causes Rocky Mountain spotted fever. The detection of this bacterium in ticks at Turnbull National Wildlife Refuge (TNWR) indicates a potential risk to human health. In order to follow up on this discovery, we had two separate objectives. First we developed a high …
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Rickettsia prowazekii and its ‘Junk DNA’: The Identification and Characterization of Small RNAs
As the etiologic agents of Rocky Mountain spotted fever and epidemic typhus, Rickettsia are obligate intracellular Gram-negative pathogenic bacteria. Genomic sequencing determined that ~24% of the Rickettsia prowazekii genome was noncoding DNA due to genomic reduction. Regions of bacterial …
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Effects of Blood Contamination on Cerebrospinal Fluid Cell Counts, Protein, and D-dimer Concentrations
… with a variety of infectious (Rocky mountain spotted fever), non-infectious inflammatory (granulomatous meningoencephalitis, steroid-responsive meningitis), traumatic (intervertebral disc disease, spinal fracture), and neoplastic (meningioma) diseases. When all dogs with CNS diseases were …
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Molecular Detection and Characterization of Rickettsia sp. in Hard Ticks Collected in Nacogdoches, Texas
<p>The number of cases of tick-borne diseases is increasing in the United States. Many efforts to control ticks have been made and are continuously being developed. These methods include surveillance of ticks and detection of the tick-borne pathogens.This study examined hard ticks in Nacogdoches, …
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Detection of zoonotic bacterial pathogens in multiple hosts using a microbiome approach and molecular characterization of Anaplasma phagocytophilum
… AFI had prior exposure to Bartonella spp., spotted fever group Rickettsia, Coxiella burnetii and Leptospira spp. Low levels of West Nile and Sindbis, but no Rift Valley fever virus exposure were found. In a separate study, the molecular detection of a bacterium closely related to Anaplasma …