Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"spontaneously hypertensive rats"”.
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Effects of ovokinin on isolated aortas of guinea pigs, normotensive and spontaneously hypertensive rats
… aortic rings from guinea pigs, normotensive rats, and spontaneously hypertensive rats were exposed to phenylephrine, prostaglandin F2a, potassium chloride, or bradykinin. Bradykinin contracted guinea pig and spontaneously hypertensive rat aortas, however, it had no effect on normotensive rat …
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Central autonomic control in spontaneously hypertensive rats: a study on phasic phenomena during rapid-eye-movement sleep
… sleep, the arterial pressure shows phasic hypertensive events which are superimposed upon the tonic level of arterial pressure. These phasic increases in arterial pressure are accompanied by an increase in heart rate (Sei & Morita, 1996; Silvani et al., 2005). Thus, rapid-eye-movement sleep …
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Static Mechanical Characteristics of the Small Collecting Vein and the First-Order Venule in the Denervated Small Intestines of the Wistar, Wistar-Kyoto, and Spontaneously Hypertensive Rats
… is important. In addition, veins in hypertensive animals appear to be stiffer than their controls; thus microvascular assessment of the hypertensive venous system is needed. The two hypotheses of this project were that (1) wall structure of a venule is a significant factor in …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
… generated from heart and aortic tissues of the Spontaneously Hypertensive Rats and Wistar Kyoto Rats. The tissue-selective and pathologically induced splicing profiles of 10 alternatively spliced exons assessed indicated a striking alteration in exon utilization and splicing patterns. This study …
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A study of biochemical and physiological properties of normal and functionally impaired skeletal muscles
… impaired rat muscles from normotensive and spontaneously hypertensive rats, (ii) single, skinned fibre preparations, and (iii) a combination of biochemical [SDS-polyacrylamide gel electrophoresis (SDS-PAGE) analyses of Myosin Heavy Chain (MHC) isoform composition in single fibres and whole …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… factors for hypertension. Fifty percent of all hypertensive patients are also insulin resistant. Both hypertension and insulin resistance are again risk factors for other cardiovascular diseases such as atherosclerosis and heart fai lure. The nature of the association between hypertension and …
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Vagus Nerve Stimulation In Hypertensive Rats: Assessing Pathophysiology Using ECG And Pressure Data
… to attenuate the development of hypertension in spontaneously hypertensive rats. Hypertension was induced via a high salt diet and rats were randomized into two groups: Sham Control (n=6) and VNS Treatment (n=6). In vivo blood pressure and electrocardiogram (ECG) were monitored continuously by an …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
… aortic samples of 5-week and 18-week old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were passaged four times and then separately incubated in collagen for two days on a cylindrical mandrel. The resulting tissue rings were subjected to repeated 10% strain …
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Magnesium Regulation of Calcium in Essential Hypertension
… A genetic model of essential hypertension, spontaneously hypertensive rats (SHR), and its control strain Wistar Kyoto (WKY) were used to investigate a possible environmental causal factor, cellular magnesium deficit, and its impact on the functional ability of the calcium ATPase. Rats were …
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Mechanisms by Which Exercise Training Attenuates Blood Pressure in Animals: Roles of Cytokines, Oxidative Stress, and Glycogen Synthase Kinase-3â
… people worldwide. Currently available anti-hypertensive medications are found to be effective in reducing blood pressure (BP), but still more than 50% of those diagnosed with hypertension fail to respond to these anti-hypertensive regimens. Although hypertension has multiple etiologies, …
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
… and diastolic blood pressure in normotensive and spontaneously hypertensive rats. Renal protection with PDE1 inhibition was tested in mouse model of DKD, featuring a combination of diabetes, nephron loss and arterial hypertension. In this model, a PDE1 inhibitor caused a significant improvement in …
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Characterization of Sympathetic Ganglion Sensitivity to Substance P in a Genetic and a Non-Genetic Rat Model of Hypertension.
… heart rate (HR) and blood pressure (BP) in hypertensive than normotensive rats due to upregulation of the NK<sub>1</sub> receptor. These experiments were designed to determine the cellular basis for the enhanced ganglionic responsiveness to NK<sub>1</sub> agonists in spontaneously …
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Vascular action of glycine in hypertensive rat models
… in blood pressure (BP) in both normotensive and hypertensive rats. These responses were abolished in the combined presence of the Ca2+ activated small and intermediate conductance K+ channel inhibitors, apamin and Tram-34/charybdotoxin. In contrast, intravenous administration of glycine evoked a …
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Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans
… women. The present study treated normo- and hypertensive female rats and postmenopausal women with oestrogen for short and longer time periods. We also investigated the acute effect of 17b-estradiol on isolated small resistance arteries and the effects of oestrogen treatment on vascular …
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Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension
… people worldwide. Currently available anti-hypertensive medica-tions are found to be effective in reducing blood pressure (BP), but still more than 50% of those diagnosed with hypertension fail to respond to these anti-hypertensive regimens. Very recently, role of toll-like receptors (TLRs), …
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Role of magnesium ions in the excitation of vascular smooth muscle. Effects of hypermagnesaemia and hypomagnesaemia on drug-induced contractions of mammalian arteries with special reference to the involvement of changed tissue calcium ion concentration or distribution in the observed responses.
… arteries from weight matched normotensive and spontaneously hypertensive rats (SHR). No differences in response to NA or ATP when extracellular [Mg 2+ ] was either increased or reduced were observed in the SHR compared to the normotensive animal. However, a difference in calcium dependence was …
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Model-based Analysis of Myocardial Microstructure for Left Ventricular Mechanics using MRI
… magnetic resonance imaging (DWI) of healthy rats and end-stage spontaneously hypertensive rats was conducted. No evidence of remodelling of orientations or increased global myofibre disarray was found in the diseased rats, but hypertension did affect regional disarray. Hypertension had no …
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