Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"spontaneous regression"”.
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T-cell responses to human papillomavirus in men with anal high-grade squamous intraepithelial lesions
… was 1.2%. This was the first study to quantify a spontaneous regression rate from HSIL, which was common at 23.5% per year. To further understand the role of the cellular immune response in anal HSIL spontaneous regression, two assays were developed to measure systemic HPV16-specific T-cell …
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Neuroblastoma: A Theoretical Dose Dependent Study With Therapeutic Implications
… an aggressive metastatic form of the disease, spontaneous regression has also been well documented. Individualized treatments are required due to the spectrum of disease staging, with MTD not necessary for many patients. Herein I propose several theoretical experiments that I believe will …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
… heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to aggressive disease. Here we define a …
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AN INQUIRY OF THE SR/CR MOUSE PHENOTYPE AND ADVANCES REGARDING THE SEARCH FOR AN ANALOGOUS HUMAN TRAIT
… breeding studies found that this trait, known as Spontaneous Regression/Complete Resistance (SR/CR) is heritable among 30 to 40 % of offspring in an autosomal manner, thus enabling extensive characterization studies to occur among a colony record comprising over 12,000 mice to date. These studies …
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The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
… state. In subtype MS neuroblastoma, tumours can spontaneously regress, in which case children are cured for life. The mechanisms behind spontaneous regression are poorly understood, but the main hypothesis is that the cells enter a terminal differentiation programme. Thus, harnessing the latent …
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Molar pregnancy: A fifteen - year experience of a single tertiary institution
… did not require chemotherapy as they achieved spontaneous regression after the second evacuation. Suction evacuation was performed in 97.4%. With regards to follow up, 44.3% of patients defaulted post evacuation surveillance and care. Conclusion: As the incidence of molar pregnancy in our …
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Spontane Regression experimenteller Gliome - Vergleich des Spontanverlaufes intracerebraler Gliome bei immunkompetenten und thymektomierten Ratten anhand immunhistologischer und MRT-Studien im Rahmen der C6-Gliomsphäroidimplantation
… gemachten Beobachtung, dass es zu einer Spontanregression experimenteller Gliome kommt. Dies geschah mittels eines Vergleichs des Spontanverlaufs intracerebraler Gliome bei immunkompetenten und thymektomierten Ratten anhand immunologischer und MRT- Studien. Verwendet wurden C6-Rattengliomzellen. …