Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"spontaneous pain"”.
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
<p>Ongoing (apparently spontaneous) pain at rest is a major complaint of patients suffering from many forms of acute and chronic pain, including acute and persistent postsurgical pain. Accumulating evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity …
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CaMKIIbeta in Pain and Addiction
… efforts for improvement, treatment of chronic pain remains inadequate and comes with major side effects like addiction, underscoring the critical need to identify innovative therapeutic targets for its treatment. Ca2+/calmodulin dependent protein kinase II (CaMKII) represents a promising target …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
Abstract : Contrary to popular beliefs, chronic pain is not only a set of symptoms, but a bona fide pathology that the drugs currently available are not sufficient to efficiently relieve. There is thus a need to modify our approach to discover new analgesic agents, taking into consideration the …
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… and costs billions to the global economy with painful, inflamed joints being the major clinical symptoms. Knee joints are innervated by the distal ends of dorsal root ganglion (DRG) neurons and hyperexcitability of knee-innervating DRG neurons (knee neurons), through a process called peripheral …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
Neuropathic pain, a debilitating condition, occurs as a consequence of nerve injury with symptoms such as spontaneous pain, hyperalgesia, and allodynia commonly reported. In animal models of peripheral nerve injury, there is accumulation and proliferation of microglial cells in the injured spinal …
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Spinal cord plasticity in peripheral inflammatory pain
Inflammatory pain is a debilitating condition that can occur following tissue injury or inflammation and results in touch evoked pain (allodynia), exaggerated pain (hyperalgesia) and spontaneous pain, yet the neural plasticity underlying these symptoms is not fully understood. However, it is known …
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Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
Pain is a complex sensory and emotional experience that results from the interaction between peripheral nociceptive input and central processing in the nervous system. Despite its clinical relevance and social impact, the management of pain, particularly chronic pain remains a significant …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
<p>Postsurgical and neuropathic pain are each clinically common, and often associated with ongoing pain. Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors. Preclinical studies using rodent neuropathic models have concentrated on allodynia driven by OA generated in …