Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"spontaneous neuronal activity"”.
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Molecular Mechanisms of Melatonin Action on the Rat Suprachiasmatic Nucleus: An in Vitro Analysis
… the SCN generates a near 24-hour pattern of spontaneous neural activity that may communicate timing between cells of the SCN as well as in targets of SCN projections. The timing of the molecular and neural oscillations of the SCN can be adjusted by various stimuli, including the pineal …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
… arrays and RNA-seq, we recorded altered spontaneous neuronal activity and co-occurring changes in gene expression that both validated established pathways and identified novel targets for future studies of HIV neurotoxicity. In part two, we focused on combatting myeloid cell-mediated …
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Developmental trajectory of functional neocortical networks in an in vitro mouse model of Rett syndrome
… may reveal how genetic mutations influence neuronal circuitry relevant to behaviour. Investigating how microscale functional networks are disrupted in RTT in humans remains challenging. In contrast, Mecp2-deficient mice recapitulate RTT-like features and reveal early synaptic deficits. …
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Graphene Brain on a Chip Platform for the Study of Neurodegeneration
… mechanisms behind the degradation of the neuronal network. This indicates a gap in the understanding of how neurodegenerative diseases and PD initiate and propagate. Therefore, graphene microelectrode arrays (MEAs) were explored to bridge this gap. However, there are currently no protocols …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… disorders suffer from an imbalance in neuronal and circuit excitability and present with seizure or epilepsy as the common comorbidity. The onset of epilepsy can be a result of an acquired brain injury (such as a trauma) or a genetic mutation in some genes. It is widely accepted that …
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Statistical analysis of neuronal data: Development of quantitative frameworks and application to microelectrode array analysis and cell type classification
… for the analysis and classification of neuronal data from a variety of contexts. Firstly, I investigate methods for analysing spontaneous neuronal network activity recorded on microelectrode arrays (MEAs). I perform an unbiased evaluation of the existing techniques for detecting ‘bursts’ …
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Mechanisms of inhibition and neuronal integration for signal processing in the primary auditory cortex of the Mongolian gerbil (Meriones unguiculatus)
… Bicuculline generally increased the spontaneous neuronal activity and enhanced and prolonged onset responses to sound. Application of bicuculline often resulted in a shift of the most sensitive frequency of the neurons’ receptive fields and a decrease of threshold (5.5 dB). A …
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Optimising Recording & Stimulation Performance of Neuronal Microelectrode Arrays through Macroporous Conducting Polymer Modification
… characterisation for properties central to neuronal recording and stimulation, comprised (i) cyclic voltammetry (CV) to yield CSCc, (ii) voltage transient measurements (VTM) to yield CIL and (iii) electrochemical impedance spectroscopy (EIS) to yield impedance spectra and thermal noise …