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Showing 1 to 3 of 3 for “"spiroketals"”.
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Continued Progress Towards Efficient Syntheses Of Cephalostatin North 1 Analogs
… stereoselective synthesis of anti-cancer spiroketals is presented. The development of a new Plug and Play' titanium(II) alkylidenation approach for the synthesis of α-functionalized spiroketals is presented in Chapter 3. Highlighting the new strategy, is the process efficient synthesis of …
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Synthetic Studies towards Opaliferin, a Tetracyclic Polyketide Metabolite
… consistently observed as the major product with spiroketals 358a,b only detected in trace amount. A revised synthetic strategy was finally devised, to employ hemiacetalisation/oxa-Michael cyclisation to build a spiroketal precursor for opaliferin (12). Successful preparation of advanced silyl …
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Methods in Total Synthesis: Development of a 2nd-Generation Synthesis of CJF-III-288, and Synthetic Efforts Towards the Total Synthesis of Sequoiamonascin A
… of synthetic fragments, such as [5.5]- and [5.6]-spiroketals, important pharmacophores found in many biologically active natural products. Continuing our program in Radical Relay Chemistry (RRC), the [5.6]-spiroketallactone in Sequoiamonascin A was an excellent target to demonstrate the RRC …