Global ETD Search
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Showing 1 to 2 of 2 for “"spirocycle"”.
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Studies within Fragment-Based Drug Discovery: Library Synthesis and Hit-to-Lead Optimisation
… exit vectors were incorporated within each core spirocycle, and the ability of these handles to effect a diverse set of chemical modifications was exemplified through the generation of 16 (a total of 21 in collaboration) examples. Computational studies highlighted the excellent physicochemical …
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SYNTHESIS OF ALL-CARBON SPIROCYCLES BY INTRAMOLECULAR IRON-MEDIATED DIENE/OLEFIN CYCLOCOUPLING
… attempting to synthesize a simple all-carbon spirocycle by in situ formation of the Fe-complex in the final step, efforts were directed to a model study using a different approach to construct a 4-pentenyl-substituted 2-methylcyclohexadiene-iron complex as a spirocyclization precursor. …