Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"spine morphology"”.
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
Dendritic spines are the main sites of synaptic input onto excitatory neurons. As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a …
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The rule of Myosin II and Rap2 in synaptic structure and function
… are Hebbian plasticity and changes in dendritic spine morphology. Recent proteomics studies have uncovered many proteins that reside in the synapse and could play critical roles in these processes. Among these are the molecular motor myosin II and the Ras family GTPase Rap2. Myosin II can move …
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The Role of DNA Methylation in Addiction and Depression
… cocaine selectively increases thin dendritic spines on NAc neurons and that DNA methylation is both necessary and sufficient to mediate these effects. I then used complementary genome wide techniques aimed at identifying cocaine-induced DNA methylation at gene targets. Transcriptional …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… protrudin's effects on intracellular transport, morphology, and protein localisation in neurons, and found varied but specific effects on different cellular systems. In particular, protrudin does not have any effect on the transport of late endosomes in CNS neurons — despite evidence for this …
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The Effects Of Vertebral Morphology And Composition On Stem-Tetrapod Intervertebral Joint Functional Behavior
… tested potential relationships between their morphology and function experimentally. Thus, the effects of complex vertebral forms on spinal rigidity, correlations to new habitat invasions or reinvasions, and range of motion remains unclear. My dissertation integrates cutting edge methods in …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… pyramidal neurons: dendrites and dendritic spines, and whether these alterations differ across brain region, cortical layer, cell type, or antipsychotic treatments. Formalin-fixed tissue blocks from frontopolar cortex, Area 10, and primary visual cortex, Area 17, were acquired from a pool of …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… plays a critical role in maintaining dendritic spine morphology and synaptic plasticity. Our collective results demonstrate a central role for Cdk5 in regulating both presynaptic and postsynaptic functions and provide better insight into how specific targets of Cdk5 can impact a general …
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WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… animals exhibit a trend toward increased stubby spine representation on basal dendrites. Additionally, I report preliminary data describing deficits in GABAAR expression and trafficking in the adult WWC2 KO and heterozygous KO hippocampus, indicating that regulation of GABAAR expression and …
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Functional and ultrastructural investigation of mouse and human dendritic spines
Dendritic spines are the physical site of the majority of excitatory synaptic connections in the mammalian brain. Their complex morphological attributes and protein composition have inspired decades of theoretical and experimental work on how classes of dendritic spines differentially sculpt input …
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Characterising the role of GPR50 in neurodevelopment and lipid metabolism
… GPR50 transfection also lead to a shift towards spine maturity although it had no effect on spine morphology, suggesting GPR50 enhances spine development but may not alter synaptic strength. The effect of GPR50 on neuronal morphology may be driven by actin remodelling. Immunocytochemistry showed …
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When good synapses go bad: dendritic spine dysgenesis in a mouse model of Fragile X mental retardation
… and interesting is a pattern of dendritic spine “dysgenesis”, found in patients and animal models of the disorder. Specifically, dendritic spines, thorn-like protrusions associated with synapses, appear “immature”: often exhibiting abnormal length and shape, and found in higher than typical …
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… brain regions may induce changes in dendritic spine morphology, as well as in the consolidation of memory strength and drug-seeking behaviour. In conclusion, the present thesis demonstrates, by applying a wide range of bioanalytical techniques, that the anti-ADHD drug, MPH, has major effects …
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
… synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that modulating ADAM10 localization and activity at synaptic sites regulates its processing of N-Cadherin. This indices …
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Studies on the cell wall of dinoflagellate resting cysts : morphological development, ultrastructure, and chemical composition
… from thecate, actively swimming planozygote to spine-bearing, morphologically mature hypnozygote occurs within 10-20 minutes. The basic mechanism consists of dramatic cell expansion resulting from the widening of an interstice between the planozygotic cytoplasm and a balloon-like membrane …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
… see if these changes in behaviour reflect in the morphology of neurons, particularly the dendritic spines dimension and membrane viscoelasticity. To do this, a primary X. laevis neuron-muscle co-culture was developed from the literature. The cultures were treated with the same pharmacological …