Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"spine formation"”.
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis and cell polarity establishment have also been defined. The neuronal proteins a1- and a2-chimaerins belong to a group of Rac and …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
… that FARP1 and Rif might exert in dendritic spine formation and neurite outgrowth. Also, the N-terminal FERM domain of FARPs is known to interact with the cytoplasmic domain of Plexin. To interrogate how FERM interacts with Plexin and how this interaction might regulate Plexin signaling, I …
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Investigating the Molecular Function of APP Interacting Proteins in Synaptic Neuromodulation
… adhesion molecule implicated in dendritic spine formation, neurite outgrowth, and synaptic transmission, often in association with its binding partner, amyloid precursor protein (APP). First identified as an ASD risk gene, evidence also suggests a potential role for CNTN4 in AD, but the …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… suggesting potential implications for synapse formation. We observed dysregulated spine density in the motor and somatosensory cortices from TrkB.T1-deficient astrocytes relative to control astrocytes. These findings suggest that TrkB.T1 deficiency adversely affects normal astrocyte …