Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"spindles"”.
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Hydrostatic machine tool spindles
… type, to precision machine tool spindles. First, relations are developed that can be used to calculate the hydraulic resistances of various bearing land flows in tilted and untilted orientations. These relations are then applied to predicting the load carrying characteristics of …
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Immunolocalization of dystrophin and neurofilament protein in muscle spindles of normal, mdx-dystrophic, and denervated mice
… dystrophy patients and in the mdx mouse. Muscle spindles in the soleus of 32-week-old normal and age-matched mdx mice were examined by immunocytochemical methods to determine the localization of dystrophin in polar and equatorial regions of the intrafusal fibers. Spindles were serially-sectioned …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
… and repair. Intrafusal fibers of muscle spindles are thought to persist in a comparatively immature state as, unlike extrafusal fibers, they maintain small diameters, developmental myosins, Myf5 expression and high SC concentrations. This thesis tests the hypotheses that Pax3 expression …
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The spindles stop : Lowell, Massachusetts, and Manchester, New Hampshire respond to the collapse of the New England textile industry
Thesis (Ph. D.)--Massachusetts Institute of Technology, Program in Science, Technology, and Society, 1995.
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NREM sleep spindles and slow wave sleep in younger and elderly women: an investigation of their influence on declarative memory consolidation
… shows that slow wave sleep (SWS) and sleep spindles play an essential role in declarative memory consolidation. However, this role is not well understood in the ageing women. With advancing age, SWS and sleep spindles undergo significant decreases in duration and density, while there is a …
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Employing Intracranial EEG Data to Decipher Sleep Neural Dynamics
… memory consolidation. Historically, sleep spindles were thought to occur synchronously across the cortex, but recent findings using iEEG have identified that sleep spindles can also be local. We utilized intracranial EEG to confirm previous findings that iEEG can identify local sleep …
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Sleep oscillations and their temporal association in neocortices in mice
… wave activity (0.5 - 4Hz) and the emergence of spindles (10 - 16 Hz). Slow waves and spindles can be recorded locally in one cortical area or globally throughout the cortex. They are often temporally associated with hippocampal ripples (80 - 250 Hz). Our understanding of how local and global …
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Using Microscopy to Examine Mechanisms of Cell Division
… that in cells depleted of TPX2, multipolar spindles formed by progressive spindle pole fragmentation. Consistent with structural role for TPX2 in the spindle, I found that while normal bipolar spindles resistant to collapse to monopolar spindles after inhibition of the mitotic motor Eg5, …
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Small Molecules as Probes for Cell Division and Intracellular Transport
… positioning and mitotic index. Monopolar mitotic spindles were induced by 4 inhibitors including one that targets Polo-like kinases, evolutionarily conserved serine/threonine kinases. Using chemical inhibitors and high-resolution live-cell microscopy, I found that Polo-like kinase activity is …
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Regulation of Anaphase Promoting Complex Coactivators
… replicated DNA; ~30% of these cells have bipolar spindles. Construction of bipolar spindles in these cells is strikingly sensitive to gene dosage of the stoichiometric Cdh1 inhibitor ACM1. CDH1-m11 cells with bipolar spindles fail to progress to anaphase, suggesting that Cdh1 inhibits multiple …
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The Role of LIM Kinase 1 and its Substrates in Cell Cycle Progression
… separation and proper assembly of bipolar spindles. Phosphorylated LIMK1 is recruited to the centrosomes during early prophase, where it colocalizes with ?-tubulin. Here, we report a novel functional cooperativity between Aur-A and LIMK1 through mutual phosphorylation. LIMK1 is recruited to …
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UCHLI in the Mammalian Nervous System
… root ganglia, described degeneration of muscle spindles, and established a timecourse of degeneration of neuromuscular junctions. Presented in this thesis is the culmination of these studies.
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Learning new words: effects of meaning, memory consolidation, and sleep
… learning and sought to clarify the roles sleep spindles and different sleep stages play in word learning. Spindle activity was associated with the emergence of lexical competition effects, suggesting that sleep has an active role in word learning, and that spindles in particular are associated …
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Review of recent morphological findings on the neuromuscular spindle
… entry and distribution of nerve supply, the spindles usually being located in the neighborhood of the main intramuscular trunks, not necessarily occupying the muscle belly or region of nerve entry of the muscle, as was until recently believed to be true. The connective tissue capsule is …
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Strategies for developing ultrathin, high-density, actively multiplexed neural mapping device
… resolution. Brain activities, such as sleep spindles, single-trial visual evoked responses, and electrographic seizures could be successfully recorded. Analysis of the recorded data reveals the propagation of the punctual spatial patterns composed of planar and spiral waves during epileptic …
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Dynamics and precursor signs for phase transitions in neural systems
… model for the thalamocortical loop for sleep spindles is presented. Numerical simulations of these networks confirms spiking consistent with reported in vivo measurement results, and provides supporting evidence for precursor indicators of imminent phase transition due to occurrence of …
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Role of phosphatases in the end-on conversion process
… at kinetochores of both monopolar and bipolar spindles; induce defects in the end-on conversion process in monopolar spindles and prolong mitosis time with increased Mad2 levels at the outer-kinetochore. A kinase inhibitor assay showed that kinetochore-microtubule attachment defects in Astrin …
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Spindle organization in three dimensions
… takes place on bipolar, microtubulebased spindles. Here, C. elegans is used to analyze spindle organization under both mitotic and meiotic conditions. First, the role of SAS-4 in organizing centrosome structure was analyzed. Partial depletion of SAS-4 in early embryos results in …
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