Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"spindle positioning"”.
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… FAM83 member known to localise to the mitotic spindle. RNA interference approaches targeting FAM83D have been reported to impact chromosome alignment and cause a delay in the timings of cell division. Whilst all FAM83 proteins appear to associate robustly with the CK1 alpha isoforms (CK1α), …
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Molecular and functional characterization of tubulin isotypes in budding yeast (Saccharomyces cerevisiae)
… roles in MT-mediated processes, particularly spindle positioning and effective spindle morphogenesis. The budding yeast mitotic spindle comprises three different MT populations that must be properly coordinated to ensure that the spindle is fully functional. We exploited the single isotype …
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Mechanisms of regulation of the spindle position checkpoint kinase, Kin4
… this problem is generally solved by the positioning of the mitotic spindle according to these spatial cues. Defects in spindle positioning can lead to the generation of cells with incorrect organelle, genetic and molecular contents, fate and/or, spatial orientation. Cells have evolved …
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Regulation of microtubule attachment at the kinetochore and cell cortex
… microtubule cytoskeleton that forms the mitotic spindle. To assemble the mitotic spindle, the two centrosomes radially nucleate dynamic microtubules that make important connections with kinetochores and the cell cortex. Kinetochores mediate the connection between the chromosomes and microtubule …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
<p>Robust regulation of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only …
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The role of cell division during tissue morphogenesis
… diversity. This is often regulated by the positioning of daughter cells post-mitosis. The goal of this dissertation research is to determine the mechanisms that place daughter cells, and how this contributes to tissue development. First, the zebrafish left-right organizer, Kupffer’s vesicle …
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Flows inside cells: From natural cytoplasmic streaming to microfluidic systems
… awaiting fertilisation. Inside the oocyte, the spindle, which is the protein structure responsible for dividing genetic material in a cell, must maintain its position near the cell cortex (the thin actin network bound to the cell membrane) for many hours. However, the cytoplasmic streaming that …
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Identification and Analysis of A Novel Role For The to usled-Like Kinase In Regulating Mitotic Spindle Dynamics
… unanticipated requirement for TLK-1 in mitotic spindle assembly and positioning. Normally, in the newly-fertilized zygote (P<sub>0</sub>) the maternal pronucleus migrates toward the paternal pronucleus at the posterior end of the embryo. After pronuclear meeting, the pronuclear-centrosome …