Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"spindle orientation"”.
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
<p>Robust regulation of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
… cell fate determinant Numb, as well as mitotic spindle orientation in neuroblasts. The other player is Drosophila cytoplasmic dynein light chain 1, also named Cut up (Ctp). Ctp localizes at centrioles and controls the mitotic spindle orientation in neuroblasts. Ctp directly interacts with a …
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
… rely on the proper positioning of the mitotic spindle. Consistently, defects in epithelial polarity and spindle orientation are often coupled with loss of tissue architecture and altered proliferation. Since mitotic spindle orientation determines the axis of cell division, in stem cells it …
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Regulation of Asymmetric Cell Divisions in the Developing Epidermis
… organizing and shaping a tissue. Mitotic spindle orientation can be coupled with cell fate decisions to provide cellular diversity through asymmetric cell divisions (ACDs), in which the division of a progenitor cell results in two daughters with different cell fates. Proper tissue …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
… neurogenesis, potentially by directing mitotic spindle orientation during precursor divisions, thereby regulating the symmetric and asymmetric nature of radial precursor divisions.
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Novel interactions and functions of the Adenomatous polyposis coli protein
… adhesion and additionally implicate MINK1 in spindle orientation via the phosphorylation of ERM proteins.
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… ERM proteins play an essential role in mitotic spindle formation, orientation and function and in cell migration. APC, too, has been linked to spindle orientation and MINK1 is phosphorylated during mitosis. Investigating the functional link suggested by these observations, I found that MINK1 …
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
… plays an essential role in cell fate decisions, spindle orientation, and morphogenesis in the early embryo. src-2 mutant animals appeared wild type under all conditions examined. The src-1 src-2 double knockout phenotype was indistinguishable from the src-1 single mutant, suggesting that src-1 …
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
… interactions, adequate force balance and precise spindle orientation are the keys in the maintenance of a mono-layered epithelium, especially upon mechanical stress induced by morphogenesis.
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The evolution of neuronal progenitor cell division in mammals: The role of the abnormal spindle-like microcephaly associated (Aspm) protein and epithelial cell polarity
… the cell biological role of the Aspm (abnormal spindle-like microcephaly associated) protein in regulating brain size was investigated. Specifically, Aspm function in symmetric, proliferative divisions of neuroepithelial (NE) cells was analyzed. It was found that Aspm expression in the mouse …
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… FAM83 member known to localise to the mitotic spindle. RNA interference approaches targeting FAM83D have been reported to impact chromosome alignment and cause a delay in the timings of cell division. Whilst all FAM83 proteins appear to associate robustly with the CK1 alpha isoforms (CK1α), …