Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"spindle midzone"”.
-
Experiments concerning the mechanism of cytokinesis in Caenorhabditis elegans embryos
… analyze the relative contributions of different spindle parts – microtubule asters and the midzone - to cytokinesis furrow positioning. I developed a UV laser-based severing assay that allows the spatial separation of the region midway between the asters and the spindle midzone. The spindle is …
-
Examining Intracellular Phosphorylation Gradients During Cell Division
… such as chromosome-microtubule attachment and spindle midzone formation. Previously, spatial phosphorylation gradients have been reported for CPC substrates, raising the possibility that CPC-dependent signaling establishes order on the micron-length scale in dividing cells. However, this …
-
Examining Mechanisms Regulating Microtubule Assembly and Function
… such as neurons. In dividing cells, a bipolar spindle assembles from microtubules and partitions genetic material into two daughter cells. Proper microtubule function in these diverse contexts depends on the assembly dynamics of microtubules and their organization into specialized arrays. Both …
-
Role of Molecular Motors and Maps in Spindle Dynamics and Chromosome Segregation in the Fission Yeast Schizosaccharomyces Pombe
… segregation is achieved by the mitotic spindle, which is composed of microtubules (MTs), motors and microtubule associated protein (MAPs). Motors such as kinesins generate forces within the spindle while MAPs perform functions such as organize the spindle pole and maintain the bipolar …
-
Regulated Recruitment of the Chromosomal Passenger Complex to Chromatin and Microtubules Promotes Accurate Cell Division
… attachments and activating the spindle assembly checkpoint (SAC). Both functions require Aurora B activation, which is promoted by its binding to the C terminus of the CPC subunit INCENP, and by localization to the inner centromere, which requires the N terminus of INCENP. Inner …
-
Regulation of polarised trafficking by Klp98A
… along the microtubule-based anaphase-specific spindle midzone, termed the central spindle. During SOP division, the central spindle becomes asymmetric, with a higher density of microtubules on the anterior side. Since Klp98A is a plus-end directed motor, this biases the motility of early …