Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"spindle elongation"”.
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REGULATION OF CHROMOSOME SEGREGATION BY CONSERVED PHOSPHATASE CDC14 AND KINASE CDC5
… and their bi-orientation on the mitotic spindle. Chromosome segregation initiates only after each sisters pair is correctly aligned onto the microtubules emanating from the spindle poles. Next, Esp1-mediated cleavage of cohesin is required to trigger anaphase onset while the physical …
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The Mitotic Exit Network detects spindle position and anaphase entry
… prior to cytokinesis. The MEN is regulated by spindle position. The MEN GTPase, Tem1, is inhibited as long as the entire spindle resides in the mother cell. Tem1 becomes active when spindle elongation along the mother-daughter axis drives half of the nucleus into the bud. If spindle elongation …
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CDK control of mitotic progression in Saccharomyces cerevisiae
… mitotic CDK activity was necessary for the elongation of the mitotic spindle in anaphase. This requirement for mitotic CDKs is independent of cohesin removal and thus constitutes a novel role for CDK activity in mitotic progression. The dual roles of CDK in initiating loss of …
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Insights into Shugoshin localization and function in S. cerevisiae chromosome segregation
… to prevent chromosome segregation errors and spindle elongation in the absence of cohesin cleavage.
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Mitotic Exit Control in Budding Yeast: Regulators and Dynamics
… Exit Network (MEN) indirectly activated by spindle elongation through cohesin cleavage by the proteolytic function of Esp1. The MEN contributes strongly to ME efficiency. Esp1 contributes to Cdc14 release and ME kinetics mainly through cohesin cleavage: the Esp1 requirement can be largely …
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Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
… centrioles, flagellum, kinetochores, and mitotic spindles). The changing roles require the cytoskeleton to be both dynamic and static in nature. Guiding these processes are a network of proteins that direct cellular behavior through their ability to bind microtubules (MTs) in a spatial- and …
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Molecular and functional characterization of tubulin isotypes in budding yeast (Saccharomyces cerevisiae)
… roles in MT-mediated processes, particularly spindle positioning and effective spindle morphogenesis. The budding yeast mitotic spindle comprises three different MT populations that must be properly coordinated to ensure that the spindle is fully functional. We exploited the single isotype …