Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"spindle checkpoint"”.
-
Safeguard of Mitosis: The Spindle Checkpoint
… attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been implicated in cancers, birth defects, and other human diseases. In presence of kinetochores that are not attached …
-
Regulation of the spindle checkpoint by Mad2 binding proteins
The spindle checkpoint ensures the fidelity of chromosome segregation by delaying anaphase until all sister chromatids form proper bipolar attachments to the mitotic spindle. Spindle checkpoint proteins localize to unattached or maloriented kinetochores in mitosis and generate a signal that …
-
The spindle checkpoint : Bubs, Mads, and chromosome-microtubule attachment in budding yeast
… pool of Mad proteins may be required for spindle checkpoint-independent functions such as invoking metaphase arrest following DNA damage.
-
The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
The spindle checkpoint is an essential mechanism to ensure accurate chromosome segregation during mitosis. The checkpoint signal originates from the kinetochore, which is a huge protein assembly on centromeric chromatin. Kinetochore is also the receptor for spindle microtubules, which enables it to …
-
Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… in chromosome segregation and tumorigenesis. The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase onset until all kinetochores achieve bipolar attachment to the mitotic spindle. Abrogation of the mammalian spindle checkpoint can cause chromosomal instability (CIN), …
-
Regulation of Progression through Unperturbed Mitosis and in the Presence of Environmental Stress
… genome. Surveillance pathways like the mitotic spindle checkpoint have evolved to prevent mitotic defects effectively. The molecular basis of these regulatory mechanisms is particularly well understood in budding yeast. It is not entirely clear to what extent these findings are valid for other …
-
The role of ZW10 and its binding partners in chromosome segregation
… chromosomes to microtubules of the mitotic spindle in a bipolar fashion and monitor the state of the kinetochore-microtubule attachment. In case errors are present, a monitoring mechanism, the spindle assembly checkpoint, inhibits metaphase to anaphase transition until proper bipolar …
-
TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… cells are equipped with multiple defenses. Checkpoints can sense problems and halt a cell’s progression through the cell cycle in order to allow repairs. More drastically, cells can also prevent passing on mutations to progeny by triggering apoptosis, or programmed cell death. This work will …
-
Molecular architecture of the Saccharomyces cerevisiae kinetochore
(cont.) checkpoint proteins Bub lp and Bub3p are recruited to the kinetochore as part of the normal cell cycle in budding yeast, whereas Madlp and Mad2p are recruited only in response to damage to the CEN-kinetochore-MT connection. Analysis of specific S. cerevisiae kinetochore mutants indicates …
-
Detection of Aneuploidy for Chromosomes 7 and 8 Using Fluorescence <i>In Situ</i> Hybridization in Patients with Aplastic Anemia and Sequencing of the Mitotic Checkpoint Gene hBUB1
… abnormalities.</p> <p><em>hBUB1</em>, a mitotic spindle checkpoint gene, was shown to be mutated in two colorectal cancer cell lines with high levels of aneuploidy (Cahill, et al., 1998). Although theoretically possible, conclusive evidence does not currently exist establishing a link between …
-
ELUCIDATION OF THE ROLE OF FAT10 IN TUMORIGENESIS
… effects through disruption of mitotic spindle checkpoint via interaction with Mad2. In conclusion, we have demonstrated that FAT10 plays an important role in tumorigenesis and cell malignancy, consistent with the reports of FAT10 overexpression in human tumor samples and we demonstrated …
-
Genetic and Cytological Analysis of the Spindle Assembly Checkpoint Component BUB-3 in DNA Damage Response
The spindle assembly checkpoint and the DNA damage response have been studied for decades as independent pathways exerting separate functions. However, crosstalk between these cellular processes has emerged. The extent of overlap between these pathways is still unknown, especially in multicellular …
-
Targeting chromosomal instability: screening and characterization of CIN killers.
… mitosis and normally prevented by cellular checkpoints. As CIN is not found in normal cells, it offers a cancer-specific target for therapy, which may be particularly valuable because CIN is common in advanced tumours that are resistant to conventional therapy. In this study, to identify …
-
Examining the Regulation of Cell Division by the Spindle Assembly Checkpoint
… The molecular surveillance mechanism called the spindle assembly checkpoint (SAC) inhibits chromosome segregation before all chromosomes are correctly attached (bi-oriented) on the microtubule spindle to prevent segregation errors that may lead to chromosomal instability and cell death. In this …
-
DISSECTING THE CLINICAL AND BIOLOGICAL RELEVANCE OF DIS3 GENE IN MULTIPLE MYELOMA
… amino acid metabolism, translation, and mitotic spindle checkpoint. Overall, our comprehensive assessment of the clinical and transcriptional consequences of DIS3 mutations or its deletion in MM strongly indicates that they may play an important role in the mechanisms of transformation and …