Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 356 for “"spindle"”.
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Spindle organization in three dimensions
… takes place on bipolar, microtubulebased spindles. Here, C. elegans is used to analyze spindle organization under both mitotic and meiotic conditions. First, the role of SAS-4 in organizing centrosome structure was analyzed. Partial depletion of SAS-4 in early embryos results in …
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Safeguard of Mitosis: The Spindle Checkpoint
… attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been implicated in cancers, birth defects, and other human diseases. In presence of kinetochores that are not attached …
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In vitro reconstitution of Central Spindle Motility
… the antiparallel MT overlap of the central spindle controls the asymmetric segregation of signalling endosomes containing fate determinants in only one daughter cell. A modest asymmetry in the density of microtubules within the antiparallel MT overlap of central spindle, with more MTs on the …
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Evaluation of an accessible automatic sleep spindle detector
… must take into account the number of sleep spindles, a short burst of neural oscillatory activity, demonstrating the need for good spindle detection. Currently this is done manually by sleep experts, but it is time consuming, motivating research into the creation of automatic spindle …
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Regulation of mitotic spindle biogenesis in budding yeast
Assembly of the mitotic spindle is critically dependent on centrosome duplication (spindle pole body or SPB in yeast), separation of sister centrosomes and microtubule dynamics. Activation of Cdc28 (Cdk1) by tyrosine-19 dephosphorylation is essential for centrosome separation, the first step in …
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Machine tool chatter suppression using spindle speed variation
… a boring process (2 DOF) when the speed of the spindle is modulated sinusoidally instead of being kept constant. Since the variation of spindle speed is small and independent of the tool motion, by expanding the delay terms about a finite mean delay and augmenting the system, the time dependent …
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Axially force limited grinding spindle for robotic grinding
… process. We will discuss a new type of grinding spindle which is axially compliant, allowing the position-control robot arm to be used in a force-control nature. The spindle has a disjoint force-displacement curve, effectively operating in two modes: position-control mode at first, until a …
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… cells employ a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase onset by inhibiting an E3 ubiquitin ligase called anaphase-promoting complex. The roles of two kinases- BubR1 and Mps1, …
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… cells employ a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase onset by inhibiting an E3 ubiquitin ligase called anaphase-promoting complex. The roles of two kinases- BubR1 and Mps1, …
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Regulation of Mitotic Spindle Assembly in Caenorhabditis elegans Embryos
The mitotic spindle is a bipolar microtubule-based structure that mediates proper cell division by segregating the genetic material and by positioning the cytokinesis cleavage plane. Spindle assembly is a complex process, involving the modulation of microtubule dynamics, microtubule focusing at …
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Review of recent morphological findings on the neuromuscular spindle
… concerning the morphology of the muscle spindle, however no paper giving a comprehensive and vivid picture of the mammalian muscle spindle has been published during this period. The purpose of this review is to present the most recent morphological findings on the mammalian neuromuscular …
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CHARACTERISATION OF A NOVEL SPINDLE DOMAIN IN MAMMALIAN MEIOSIS
… of microtubule networks into a bipolar spindle is essential for reliable chromosome segregation during cell division. A pair of centrioles surrounded by pericentriolar material (PCM), define the canonical centrosome that acts as the main microtubule organising centre (MTOC) during …
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Regulation of the spindle checkpoint by Mad2 binding proteins
The spindle checkpoint ensures the fidelity of chromosome segregation by delaying anaphase until all sister chromatids form proper bipolar attachments to the mitotic spindle. Spindle checkpoint proteins localize to unattached or maloriented kinetochores in mitosis and generate a signal that …
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A high-speed hysteresis motor spindle for machining applications
… for use in a new high-speed machining spindle was performed to determine critical research areas. The focus is on a hysteresis motor topology using a solid, inherently-balanced D2 steel shaft. An analytical model of the motor is devised in order to make performance predictions and …
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The Mitotic Spindle Mediates Inheritance of the Golgi Ribbon Structures
… Mitotic Golgi membranes concentrate around the spindle poles, suggesting that the spindle may control Golgi partitioning. To test this, cells were induced to divide asymmetrically with the entire spindle segregated into only one daughter cell. A ribbon reforms in the nucleated karyoplasts, …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
<p>Robust regulation of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only …
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Molecular Mechanisms of Mitotic Spindle Assembly and Accurate Chromosome Segregation
… BubR1 auto-phosphorylation in response to spindle microtubule capture by CENP-E is important for kinetochore functions in achieving accurate chromosome segregation. In the second part (Chapter 3), my colleague and I demonstrate a novel mechanism of mitotic spindle assembly in Xenopus egg …
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Mechanisms of regulation of the spindle position checkpoint kinase, Kin4
… solved by the positioning of the mitotic spindle according to these spatial cues. Defects in spindle positioning can lead to the generation of cells with incorrect organelle, genetic and molecular contents, fate and/or, spatial orientation. Cells have evolved feedback mechanisms that …
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