Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"spinal nerve"”.
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The Molecular Regulation of Spinal Nerve Outgrowth
… plasticity throughout life. Following brain or spinal cord injury, these repellent molecules are upregulated by reactive astrocytes accumulating at the lesion site, and may impede axon regeneration in this region. In this dissertation, I am presenting the results of a differential gene …
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The presence of Nissl's bodies and neurofibrillae in the freshly fixed spinal nerve cell
… even questioned their presence in the living nerve cell and have considered them as artifacts. Mollgaard, especially, in a recent article strongly doubts the existence of both in the "vitally-fixed" nerve cell. Thus it has seemed desirable to do some further work in this direction. This …
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PARTIAL SPINAL NERVE LIGATION ALTERS ANATOMICAL COMPONENTS OF OXYTOCIN SIGNALING AND THE LEVEL OF TONIC OXYTOCIN-MEDIATED INHIBITION OF NOCICEPTION
… signaling that may be altered by partial spinal nerve ligation (pSNL) injury and contribute to the apparent recovery of pain after pSNL injury in rats.
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Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
In human, the neuropathic pain evoked by nerve injury includes severe mechanical allodynia and hyperalgesia in the region where the nerve innervates. The mechanism of the development of neuropathic pain was not yet well known and the solution for it was not also elucidated. The ligation of L5 …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
… and neurons. We used a neurodegeneration model, spinal nerve ligation, in vivo, and cultured cells treated with the change of CAMs expression by RT-PCR and western blotting analysis. In nervous system, ICAM-1 mRNA was expressed in astrocytes and microglia. NCAM mRNA was expressed in astrocytes as …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
Neuropathic pain caused by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. …
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Segmentation of nerve bundles and ganglia in spine MRI using particle filters
Automatic segmentation of spinal nerve bundles originating within the dural sac and exiting the spinal canal is important for diagnosis and surgical planning. The variability in intensity, contrast, shape and direction of nerves seen in high resolution myelographic MR images makes segmentation a …
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A Fiber Count and Caliber Spectral Study of the Cat Ulnar Nerve and Some of Its Branches
… sheath, others with the latter covering only. Nerve fibers possessing both coverings are spoken of as myelinated. Fibers of the peripheral nervous system surrounded by only the neurolemma sheath are called unmyelinated. It has been reported by Duncan (’34), after observations of the dorsal and …
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Anatomical investigation of the accessory nerve
The eleventh cranial nerve, known as the accessory nerve (CN XI), consists of a cranial and a spinal component. The spinal root is responsible for the motor innervation of the sternocleidomastoid (SCM) muscle and the trapezius (TZ) muscle. During neck dissection, shoulder syndrome presents in …
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Effects of electrical stimulation and testosterone on regeneration-associated gene expression and functional recovery in a rat model of sciatic nerve crush injury
… is often suboptimal following peripheral nerve injury (PNI). Research to date indicates that the greatest success in achieving full functional recovery will require the use of a combinatorial approach that can simultaneously target different aspects of the post-injury response. In general, …
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TWO TYPES OF ROS ARE DIFFERENTIALLY INVOLVED IN SPINAL SYNAPTIC PLASTICITY AND MECHANICAL HYPERSENSITIVITY IN NEUROPATHIC PAIN
… involved in the induction and maintenance of spinal LTP and LTD are still unclear. This study investigates the type of synaptic plasticity expressed by two major types of pain-relaying neurons in the dorsal horn, excitatory spinothalamic tract neurons (STTn) and inhibitory gamma-amino-butyric …
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Cellular And Mechano-Active Material Approaches To Improve Disc Repair After Herniation
… the extrusion of NP tissue which can result in spinal nerve compression and consequent pain. The gold standard for the surgical management of symptomatic disc herniation is microdiscectomy, in which the herniated tissue is removed. This alleviates pain yet fails to repair the injured disc, …
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Pain-modulating effects of peripheral (CB2) cannabinoid receptors
… inflammatory hyperalgesia, and peripheral nerve injury-induced sensory hypersensitivity. In previous work included in my masters thesis, our laboratory has demonstrated the capacity of CB2 receptors located outside the central nervous system (CNS) to inhibit acute nociception and …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
… to cross noxious probes. Rats with a thoracic spinal cord injury (SCI), lumbar spinal nerve transection, or chronic constriction injury of the sciatic nerve, as well as their sham controls, exhibited heightened pain-avoidance behavior compared to uninjured controls. These findings have …
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Investigating molecular mechanisms of neuronal regeneration: a microarray approach.
… to the peripheral branch at the level of the spinal nerve (SN) results in axonal regeneration and reinnervation. Crush injury of the central branch in the dorsal root (DR) results in active regeneration up to the point of CNS entry at the DR entry zone (DREZ) and subsequent arrest of further …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… condition, occurs as a consequence of nerve injury with symptoms such as spontaneous pain, hyperalgesia, and allodynia commonly reported. In animal models of peripheral nerve injury, there is accumulation and proliferation of microglial cells in the injured spinal cord and macrophages …
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Regeneration of ventral roots into the dorsal horn and axoplasmic flow of acetylcholinesterase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
Nociceptors are a set of peripheral neurons responsible for the detection of noxious stimuli. They function to alert us to the presence of potentially damaging internal and environmental threats, thereby playing an important role in allowing us to react and avoid danger. Unfortunately, for over 30% …