Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"spike protein"”.
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Genetics and functions of the SARS coronavirus spike protein
… acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. Investigations, described herein, have focused on the genetic manipulation of the SARS-CoV S glycoprotein in order to delineate …
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Structural studies of SARS-CoV-2 spike protein and vesicular coats
… and therapeutic development. The SARS-CoV-2 S protein, forming a crown on the surface of the virus envelope, is responsible for the receptor interaction and facilitating entry into host cells. It is one of the main antigens and a promising therapeutic target. In my work, I expressed and …
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Aptamers that bind SARS-CoV-2 spike protein for COVID-19 rapid diagnostics and therapeutics
… novel DNA aptamers that bind to the SARS-CoV-2 spike glycoprotein with high specificity and affinity (< 80 nM). Through binding assays and high resolution cryo-EM, we demonstrate that SNAP1 (SARS-CoV-2 spike protein N-terminal domain-binding aptamer 1) binds to the S N-terminal domain. We …
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Engineering the fusion machinery core of SARS-CoV-2 spike protein for vaccine immunogen design
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Development and Characterization of A Recombinant Orf Virus Vector Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus
… sites. ORFV has evolved several immunomodulatory proteins (IMPs) that evade and/or modulate host immune responses to infection and contribute to virus virulence and disease pathogenesis. Given biological properties and unique immunomodula tor y properties, ORFV has gained significant attention in …
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Molecular and genetic studies on a SipD/IpaD-related virulence spike protein from immune-suppressive particles of a Drosophila parasitoid
… along with the wasp egg. The EVs possess spikes and contain hundreds of proteins, some of which enable wasp eggs to escape encapsulation by changing the morphology and function of hemocytes, or killing them. Previous studies have identified an abundant surface/spike protein (SSp40) from …
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Computational Analysis of Antibody Binding Mechanisms to the Omicron RBD of SARS-CoV-2 Spike Protein: Identification of Epitopes and Hotspots for Developing Effective Therapeutic Strategies
… the Omicron receptor binding domain (RBD) of the Spike protein. The study demonstrates that the Omicron variant harbors 23 unique mutations across the RBD regions I, II, III, and IV. Of these mutations, seven are shared between RBD regions I and II, while three are shared among RBD regions I, II, …
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Computational Molecular Docking Studies of Small Molecule Inhibitors With the SARS-CoV-2 Spike Protein Variants: In-Silico Drug Discovery Using Virtual Screening and Drug Repurposing Approaches
… as it evolves. In this study, we focus on the spike protein as a target for potential inhibitors. We explore two methods of inhibiting spike function, allosteric inhibition and direct inhibition. In the study of allosteric inhibition, we screened two compound libraries against two allosteric …
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Computationally Designed Peptide Binder and Molecular Beacon for SARS-CoV-2
… an ACE2-derived peptide that targets the viral spike protein receptor-binding domain (RBD). The peptide was derived utilizing the existing crystal structure of spike protein’s RBD and ACE2 to determine the linear peptide fragments that contributed the most to the binding energy of the complex. …
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Identifying and Tracking the Evolution of Mutations in the SARS-CoV-2 Virus
… with the SARS-CoV-2 sequences. Mutations on the Spike protein of SARS-CoV-2 are the most important as the spike protein mediates the viral entry into host cells. This study tracks the course of mutations on the spike protein by focusing on the haplogroups of the sequences across the world. A …
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Nanomechanical Analysis of Coronavirus Spike proteins and Correlation with Infectivity and Lethality
… between the receptor-binding domain (RBD) of its spike protein and the human cell receptor ACE2. As an increasing number of variants of SARS-CoV-2 circulates globally, estimates of infectiousness and lethality of newly emerging strains are important. Here, we provide a novel way to develop a …
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PATTERNS OF NATURAL SELECTION ASSOCIATED WITH TROPISM SHIFTS IN ANIMAL CORONAVIRUS GENOMES
… identify how natural selection may alter viral proteins priming them for tropism shifts. Statistical codon models can infer both which codon sites and genes have been subject to positive or negative selection, effectively differentiating signal between random mutations and those that may impact …
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… between raccoon dog ACE2 and the SARS-CoV-2 spike protein. Biochemical data showed that raccoon dog ACE2 functions as an effective receptor for the SARS-CoV-2 spike protein, although less efficiently than human ACE2. Structural comparisons identified key differences in virus-binding residues …
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Evolution of targets at the host-pathogen interface
… in particular – is presented. Chapter 2: Protein-coding potential of the Mtb genome <br>Using comparative genomics, I investigate the protein-coding potential of globally-distributed Mtb strains. Previous reports had suggested that the pan-genome (or all unique protein coding sequences …
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Análise do perfil epidemiológico e molecular do SARS-CoV-2 em dois municípios do estado da Bahia entre 2020 e 2022.
… mutations in the genome, particularly in the Spike protein, has influenced transmissibility, clinical severity, and public health impact. Spatial dispersion analysis of the virus requires consideration of both biological and social factors, such as population density and structural …
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DECIPHERING THE MOLECULAR MECHANISM BEHIND THE SARS-COV-2 FUSION DOMAIN
… The traditional means by which viral glycoproteins facilitate fusion is that of the six-helix bundle, within which a short, conserved sequence known as the fusion domain (FD) initiates the process as it embeds within and perturbs the target cell membrane, in turn lowering the energetic …
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CHASING VARIANTS: MAKING THE MATCH BETWEEN THE SARS-COV-2 S1/S2 CLEAVAGE SITE AND HOST CELL PROTEASES
… evasion, some have impacted the role of the S protein in fusion and host cell entry. Among these are those mutations around the S1/S2 site, which is thought to be mainly cleaved by furin during virion formation. The 681st amino acid S position in particular has been the site nonynomymous …
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Characterising the magnitude and breadth of T cell responses to SARS-CoV-2 vaccination
Spike protein which serves as the immunogen in the current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is targeted by the CD4 and CD8 T cells. While most studies frequently measure the magnitude of spike-specific CD4 and CD8 responses, only a few studies have …
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Protein and peptide-based biomaterials for treatment of COVID-19, crossing the blood-brain barrier and local delivery of antibiotics
… that can block the interaction of ACE2 and the Spike protein present in COVID-19 virus. The binding of the Spike protein to the ACE2 receptor facilitates the entry of the virus into human cells, and blocking this interaction could be a potential treatment strategy for preventing infection caused …
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Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons
… In this work, we employ a deep learning-based protein design to engineer molecular beacons that function as conformational switches for high sensitivity detection of the SARS-CoV-2 spike protein receptor-binding domain (SRBD). The beacons contain two peptides, together forming a heterodimer, …
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