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Showing 1 to 8 of 8 for “"sphingosine kinases"”.
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The role of sphingosine kinases in pulmonary fibrosis
… growth factors that regulate this transition. Sphingosine kinases (SK) are promising new targets for pulmonary fibrosis as they regulate the balance between the proapototic ceramides and prosurvival sphingosine 1-phosphate. Sphingosine kinase 1 has a profibrotic role whilst the role of …
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The role of sphingosine kinases and SKAM1 in cutaneous wound healing
Sphingosine kinases (SKs) phosphorylate sphingosine to generate the bioactive lipid sphingosine 1-phosphate (S1P). SKs and S1P regulate a diverse range of cellular processes, including cell proliferation, survival, differentiation, migration, smooth muscle cell contraction, inflammation, …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
Sphingosine kinase 1 and Sphingosine kinase 2 (SK1 and SK2) are lipid kinases which form the bioactive lipid sphingosine-1-phosphate (S1P). SKs have been widely implicated in human cancers and inflammation. This has been demonstrated to be a consequence of the actions of S1P, which acts as a ligand …
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The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… of the reported opposing roles of Degs1. The sphingosine kinase inhibitor SKi [2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole] or the Degs1 inhibitor fenretinide promoted the polyubiquitination of Degs1 (Mr = 40-140 kDa) through a mechanism involving p38 mitogen-activated protein kinase …
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INTRACELLULAR TARGETS OF SPHINGOSINE-1-PHOSPHATE
The bioactive lipid mediator sphingosine-1-phosphate (S1P) has emerged as a key regulator of a variety of important physiological functions, including cell growth, cell survival, cell motility, angiogenesis, lymphocyte trafficking, and mast cell function. S1P is formed by two different sphingosine …
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Characterization of Influenza:Streptococcus pneumoniae synergistic disease and potential for disease alleviation via sphingolipid therapy
… influenza. There is particular emphasis on sphingosine 1-phosphate (S1P) signaling, as well as control of intracellular S1P levels via sphingosine kinases (SK). Sphingolipids are involved in a multitude of cellular processes, and are tightly regulated by their metabolizing enzymes. We …
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Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
There is evidence of the involvement of sphingosine kinases (two isoforms termed SK1and SK2), which catalyse the formation of the bioactive lipid, sphingosine 1-phosphate(S1P), in various diseases including cancer. Over the last few years, metabolomics has become an increasingly critical part in …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… of El Shewy, who identified two enzymes, the sphingosine kinases (SphKs), and their product S1P, as responsible for the activation of PI-3K/Akt and MAPK pathways. Indeed, we confirmed the overexpression of SphK, mainly the isoform SphK1, in ACT compared to NA. Moreover, this was the first …