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Showing 1 to 20 of 64 for “"sphingolipids"”.
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Structural and Metabolic Studies of Sphingolipids
Made available in DSpace on 2014-12-10T23:01:00Z (GMT). No. of bitstreams: 1 7114795.pdf: 6880498 bytes, checksum: 6ad7196cbbcd286054169ee060d9ca04 (MD5) Previous issue date: 1970
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Sphingolipids in Toxoplasma gondii; synthesis and scavenging
… for new drugs is of significant importance. Sphingolipids have been shown to be essential in many different eukaryotic cell types through their roles in cell signaling and regulatory roles in cell transport. Serine palmitoyltransferase is the first rate limiting step in biosynthesis and the …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
… (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytosolic face of cis-Golgi and translocated to the plasma membrane and organelle lumen. The glucocerebrosidases degrade GlcCer in the cytosol and lysosome. GlcCer has been suggested to be an activator of …
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Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… in atherosclerosis, obesity and cancer. Dietary sphingolipids, however, can suppress intestinal inflammation. We hypothesized that dietary sphingomyelin (SM) from bovine milk can modulate the inflammatory signature and improve muscle function in mdx mice, a model of DMD. C57BL10 (WT) and mdx mice …
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The role of sphingolipids in autosomal dominant polycystic kidney disease (ADPKD)
… factor in defective renal cystic epithelia. Sphingolipids contribute to regulating these cellular processes. Two isoforms of sphingosine kinase (SK1 and SK2) catalyse the formation of the bioactive lipid sphingosine-1-phosphate (S1P) from sphingosine.;We sought to determine the effects of …
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Complex Lipids. The Sphingolipids of Beef Lung. The Occurrence of Galactosylglycerol Lipids in Plants
Made available in DSpace on 2014-12-05T19:37:48Z (GMT). No. of bitstreams: 1 6104391.pdf: 3706978 bytes, checksum: 57781e2256c377bc4e3ea6e7165008da (MD5) Previous issue date: 1961
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
… lipids, there are few such studies focused on sphingolipids. In the work below, we present initial studies that show that sphingolipids specifically regulate the tethering and docking steps of homotypic vacuole fusion, they are necessary for proper AP-3 trafficking, and they influence cell …
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Exploring the roles of key lipids in the influenza virus lifecycle
… resistance and confer universal strain potency. Sphingolipids are a host lipid that is a known influenza target. According to a long-standing hypothesis, cholesterol and sphingolipids form distinct plasma membrane domains, termed lipid rafts, that help recruit newly synthesized influenza …
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Protein-sphingolipid interactions and their role in immunity and disease
Sphingolipids are a diverse class of lipids involved in fundamental cellular processes. In addition to their role in membrane architecture, sphingolipids can act as bioactive molecules, regulate membrane protein function and be presented to the immune system as lipid antigens by CD1 family …
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Ceramidsynthese in Saccharomyces cerevisiae
… ER membrane. (iv) The synthesis rates of complex sphingolipids are drastically reduced in the absence of LAG1 and DGT1. Consequently, lag1Ddgt1D cells have a decreased portion of sphingolipids compared to the wild type. The lipid defekt is not due to lacking phosphoinositolation of ceramide, since …
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The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
… of fatty acids that we are interested in are sphingolipids, they are a class of lipids containing a backbone of sphingoid bases and aliphatic amino alcohols. Sphingolipids show potential as lipid-conjugated siRNAs as they are important structural and functional components of plasma membranes …
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Probing the formation of mammalian cell lipid microdomains with nanometer-scale imaging secondary ion mass spectrometry
… of the plasma membrane, especially that of the sphingolipids’ organization. The recent application of imaging mass spectrometry to biological samples has enabled for the chemical analysis of the plasma membrane. Through the use of a high resolution imaging secondary ion mass spectrometer …
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Anticancer Effects of Vitamin E Forms and Their Long-chain Metabolites via Modulation of Sphingolipid Metabolism
… γTE and 13’-COOHs have effects on the levels of sphingolipids in cancer cells using liquid chromatography tandem mass spectrometry. Treatment of human colon cancer HCT-116 cells with γTE or δT-13’-COOH significantly increased in intracellular dihydroceramides (dhCers) and dihydrosphingosine …
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Analysis of rat brain lipids and metabolites after antidepressant drug treatment
… an emphasis on the relatively unexplored role of sphingolipids. For this purpose, the current study used two antidepressant drugs: the tricyclic antidepressant desipramine, and the selective serotonin re-uptake inhibitor paroxetine. The effects of the drugs in rat brain regions implicated in …
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Lipid rafts in protein sorting and yeast cell polarity
… rafts, dynamic membrane domains enriched in sphingolipids and sterols, could be an important part of the picture. My thesis study dealt with the elucidation of the molecular sorting principles at the TGN and their exploitation for cell surface polarity in the yeast Saccharomyces cerevisiae. …
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A multiscale study of plasmodesmata: from channel ultrastructure to plant architecture
… of individual plasmodesmata. I show that sphingolipids, a lipid class enriched in the membranes of these structures, have a functional role in shaping the pores. Sphingolipid alterations resulting from mutation in the PHLOEM UNLOADING MEDIATOR gene or in the LONG CHAIN BASE KINASE 1 gene …
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Investigating sphingolipid behavior and function using metabolic labeling
… roles in cellular functions in multiple ways. Sphingolipids are a group of lipids that are involved in various cellular processes that are crucial for cell survival and proliferation. However, our understanding of sphingolipid function is limited due to the complexity of their behaviors and the …
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Carbon-13 magic angle spinning NMR studies of myelin membranes
… spectra of a variety of model phospholipids, sphingolipids, myelin and white matter samples, resolving and assigning over 60 resonances in the spectra of human myelin samples. Spectra of fresh bovine white matter, and subsequent myelin and lipid extract preparations, revealed essentially no …
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The mode of action of Epicoccum derived antimicrobials
… epipyrone A (DEA). Results suggest DEA affects sphingolipids and their biosynthesis in yeast, while very long chain fatty acids (VLCFAs) are possibly contributing to resistance. Furthermore, additional antifungal modes of action were indicated including oxidative stress, disruption of the …
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