Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"sphingolipid"”.
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Synthesis of Biologically Relevant Sphingolipid Analogues
… the synthesis of two different classes of sphingolipid analogues. In a first part, we aimed at the synthesis of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide. Since preliminary synthetic approaches based on a mono-protective strategy resulted in …
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Studies on a Sphingolipid From Beef Lung
Made available in DSpace on 2014-12-09T17:35:08Z (GMT). No. of bitstreams: 1 6503682.pdf: 3546657 bytes, checksum: cb7f6a9563ba1feede6f2ceeec5753df (MD5) Previous issue date: 1964
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Sphingolipid synthases of Toxoplasma gondii and other organisms
… is a necessity to explore new drug targets. Sphingolipids are essential components of eukaryotic cell membranes and signal transduction pathways. Mammals produce sphingomyelin (SM) via a SM synthase, whereas yeast, plants and some protozoa utilise an inositol phosphorylceramide (IPC) synthase …
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Investigating sphingolipid behavior and function using metabolic labeling
… roles in cellular functions in multiple ways. Sphingolipids are a group of lipids that are involved in various cellular processes that are crucial for cell survival and proliferation. However, our understanding of sphingolipid function is limited due to the complexity of their behaviors and the …
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The potential of sphingolipid depletion for the treatment of atherosclerosis
Sphingolipids have been implicated as potential atherogenic lipids. Inhibition of hepatic serine palmitoyl transferase (SPT) reduces plasma sphingomyelin (SM) levels leading to a reduction of atherosclerosis in apolipoprotein-E gene knockout (apoE-/-) mice. In my thesis I have investigated the …
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Protein-sphingolipid interactions and their role in immunity and disease
Sphingolipids are a diverse class of lipids involved in fundamental cellular processes. In addition to their role in membrane architecture, sphingolipids can act as bioactive molecules, regulate membrane protein function and be presented to the immune system as lipid antigens by CD1 family …
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Pathophysiology and Mechanism of Fumonisin B(1) Induced Disruption of Sphingolipid Metabolism
*This dissertation is a compound document (contains both a paper copy and a CD as part of the dissertation).
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Characterization of Influenza:Streptococcus pneumoniae synergistic disease and potential for disease alleviation via sphingolipid therapy
… for the aged and other vulnerable populations. Sphingolipid modulation has emerged as a potential target to ameliorate the excessive inflammation (cytokine storm) elicited by highly pathogenic influenza. There is particular emphasis on sphingosine 1-phosphate (S1P) signaling, as well as control …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… in our laboratory showed that different glycosphingolipids were involved in rHIgM22 binding at the cell surface but also that rHIgM22 treatment induced changes in the sphingolipid pattern of oligodendroglial cells (Grassi et al., 2015; S. Grassi et al., 2021). Since microglia seem to be a …
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The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
… of fatty acids that we are interested in are sphingolipids, they are a class of lipids containing a backbone of sphingoid bases and aliphatic amino alcohols. Sphingolipids show potential as lipid-conjugated siRNAs as they are important structural and functional components of plasma membranes …
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Anticancer Effects of Vitamin E Forms and Their Long-chain Metabolites via Modulation of Sphingolipid Metabolism
… prostate cancer cell death by modulation of sphingolipid metabolism, we investigated whether γTE and 13’-COOHs have effects on the levels of sphingolipids in cancer cells using liquid chromatography tandem mass spectrometry. Treatment of human colon cancer HCT-116 cells with γTE or …
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Examination of the Effects of a Sphingolipid-Enriched Lipid Fraction from Wheat Gluten on the Incidence of Diabetes in BBdp Rats
This study was designed to examine if a sphingolipid-enriched lipid fraction from wheat gluten could affect the incidence of type I diabetes in BioBreeding diabetes prone (BBdp) rats. Wheat gluten was extracted with a chloroform-methanol (CM) mixture to isolate most of the lipids. Isolated lipids …
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Zur spezifischen Interaktion von Sphingolipiden mit Membranproteinen
… einer Methode zur Untersuchung von Protein-Sphingolipid-Interaktionen. In vitro generierte COPI-Vesikel weisen eine im Vergleich zur Donormembran höhere Konzentration der SM-Spezies SM 18:0 auf (Brugger et al. 2000). Die Anreicherung der SM-Spezie könnte auf eine spezifische …
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Development of Immune Modulators Targeting Autoimmune Disorders and Pulmonary Injury: Design, Synthesis, and Biological Evaluation of Sphingolipid-Derived Sphingosine-1 Phosphate Receptor 1 Agonists
… autoimmune disorders. Therefore, their sphingolipid substrates have been a key target for immunomodulation ever since their function’s discovery. Despite extensive research, a synthetic sphingoid derivative – fingolimod – that acts as a competitive receptor expression level …
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Exploring the roles of key lipids in the influenza virus lifecycle
… resistance and confer universal strain potency. Sphingolipids are a host lipid that is a known influenza target. According to a long-standing hypothesis, cholesterol and sphingolipids form distinct plasma membrane domains, termed lipid rafts, that help recruit newly synthesized influenza …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
… and improve patient outcome. Altered sphingolipid pathway signalling has been linked with anchorage-independent survival, HGSOC disease progression and chemoresistance, however, further investigation of this pathway is required to understand how the sphingolipid pathway may mediate …
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Changes in Pancreatic and Jejunal Histopatholgy and Serum IFN-γ, TNF-α Levels in Type 1 Diabetes: Role of Chloroform Methanol Soluble Gliadin Proteins
… study in our laboratory failed to show that the sphingolipid enriched fraction of CM soluble extract of wheat gluten triggers type 1 diabetes. Therefore, to study the involvement of CM soluble gliadin proteins in type 1 diabetes, we retrospectively analyzed proteins from sphingolipid enriched …
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PLASMA MEMBRANE ASSOCIATED GLYCOHYDROLASES: KINETICS PARAMETER CHARACTERIZATION AND BIOLOGICAL FUNCTION
Plasma membrane (PM) sphingolipid pattern and content are the result of a complex network of metabolic pathways, including those potentially involving the activity of PM sphingolipid hydrolases and sphingolipid synthases (1, 2). In human fibroblasts it has been observed a crosstalk between the …
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Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
… over-expression of SK1b increases flux through sphingolipid and phospholipid pathways such that inhibition of SK1b with SKi results in a more profound increase in lipid metabolites compared with LNCaP cells. Part of this effect is in blockade of the sphingolipid rheostat and inhibition of …
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